80212-21-1

Basic information

• Product Name: (E)-2-[2-(4-methylphenyl)vinyl]-4H-chromen-4-one
• Synonyms: (E)-2-[2-(4-methylphenyl)vinyl]-4H-chromen-4-one
• CAS NO: 80212-21-1
• Molecular Weight: 262.308
• Mol File: 80212-21-1.mol

Chemical Properties

• CAS DataBase Reference: (E)-2-[2-(4-methylphenyl)vinyl]-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-2-[2-(4-methylphenyl)vinyl]-4H-chromen-4-one(80212-21-1)
• EPA Substance Registry System: (E)-2-[2-(4-methylphenyl)vinyl]-4H-chromen-4-one(80212-21-1)

Safety Data

• Hazardous Substances Data: 80212-21-1(Hazardous Substances Data)

Upstream product

• 5751-48-4 2-methylchromone 
• 104-87-0 4-methyl-benzaldehyde 
• 153854-89-8 ω-para methyl cinnamoyl 2-hydroxyacetophenone 
• 118-93-4 o-hydroxyacetophenone 
• 15851-89-5 (E)-p-methylcinnamoyl chloride 
• 1866-39-3 trans-p-methylcinnamic acid 
• 153854-88-7 2-(4-methyl cinnamoyloxy)acetophenone 
• 205308-04-9 (2Z,4E)-3-Hydroxy-1-(2-hydroxy-phenyl)-5-p-tolyl-penta-2,4-dien-1-one 

Downstream Products

• 223509-40-8 (Z)-4'-methyl-2-(α-bromostyryl)chromone 

Relevant articles and documents

Synthesis of (E)-2-styrylchromones and flavones by base-catalyzed cyclodehydration of the appropriate β-diketones using water as solvent

A low cost, safe, clean and environmentally benign base-catalyzed cyclodehydration of appropriate β-diketones affording (E)-2-styrylchromones and flavones in good yields is disclosed. Water was used as solvent and the reactions were heated using classical

(E)-2-Styrylchromones as potential anti-norovirus agents

Human noroviruses (NoV) are now recognized as the most frequent cause of outbreaks and sporadic cases of acute gastroenteritis. Despite the significant economic impact and considerable morbidity of norovirus disease, no drug or vaccine is currently available to treat or prevent this disease, therefore the discovery of anti-norovirus drugs is urgent. In the present work, a total of 12 structure related chromone and (E)-2-styrylchromones were evaluated for their potential anti-norovirus activity using the murine norovirus (MNV) as a surrogate model for human NoV. From the 12 compounds studied, six (E)-2-styrylchromones were found to have with interesting anti-norovirus activity. The best compounds of the series were (E)-5-hydroxy-2-styrylchromone and (E)-4′-methoxy-2-styrylchromone with an IC50 ≈ 7 μM. A first insight into the mechanism of action of these compounds was possible. An interesting relationship between the anti-norovirus activity and the chemical structure was observed. The present study points out that the (E)-2-styrylchromones skeleton is an important one which deserves to be developed and further explored as new antiviral drugs against NoV.

Synthesis of 4-Aryl-3-(2-chromonyl)-2-pyrazolines by the 1,3-Dipolar Cycloaddition of 2-Styrylchromones with Diazomethane

The first reported 1,3-dipolar cycloaddition of 2-styrylchromones with diazomethane afforded 4-aryl-3-(2-chromonyl)-2-pyrazolines. However, 3-aryl-4-(2-chromonyl)-1-pyrazolines have been also found as minor products of this reaction. These two series of p

Influence of the vinyl group on the calcium antagonistic activity of analogues of Fostedil

Four aryl vinyl diethyl benzylphosphonates related to Fostedil were synthesized and evalued for their in vitro calcium-inhibitory activity.None of these compounds exhibited any calcium antagonistic profile.Unlike a series of diethyl-styryl benzylphosphona