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(E)-2-(3-methoxystyryl)-4H-chromen-4-one is a complex organic compound belonging to the class of flavones, characterized by a 4H-chromen-4-one core structure with a 3-methoxystyryl group attached at the 2-position. This molecule features a conjugated system of double bonds and aromatic rings, which contributes to its potential biological activities. It is known for its antioxidant properties and is often found in natural products, such as certain plants, where it may play a role in protecting against oxidative stress. The compound's structure also suggests potential applications in pharmaceuticals and as a precursor in the synthesis of other bioactive molecules.

80212-22-2

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80212-22-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 80212-22-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,2,1 and 2 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 80212-22:
(7*8)+(6*0)+(5*2)+(4*1)+(3*2)+(2*2)+(1*2)=82
82 % 10 = 2
So 80212-22-2 is a valid CAS Registry Number.

80212-22-2Downstream Products

80212-22-2Relevant academic research and scientific papers

Structure-activity relationship study of growth inhibitory 2-styrylchromones against carcinoma cells

Lin, Chen,Lu, Pei-Jung,Yang, Chia-Ning,Hulme, Christopher,Shaw, Arthur Y.

, p. 2385 - 2394 (2013/07/26)

The structure-activity relationship study of 2-styrylchromones against carcinoma cell growth is discussed in the present report. Taking advantage of 2-styrylchromone as a molecular template, a series of structural modifications was carried out and examined on several carcinoma cell lines. Interestingly, AGS cells exhibited more sensitivity in response to methoxy-bearing compounds, of which compound 23 (3,4,5-trimethoxy group on ring B) showed the most potent activity with a GI50 value of 1.3 μM. Surprisingly, as methoxy groups in 12 and 24-27 were demethylated to generate their hydroxyl counterparts 28-32, none of them displayed appreciable activity against all carcinoma cells. We further confirmed the pivotal role of rigidity for growth inhibitory activity between the rigid 12 and its flexible counterpart 33. Taken together, in the present report, we have clearly demonstrated the structure-activity relationship study of 2-styrylchromones targeting carcinoma cell growth.

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