80225-02-1

Basic information

• Product Name: 5-p-chlorophenyl-4-tosyl-2-oxazoline
• CAS NO: 80225-02-1
• Molecular Weight: 335.811
• Mol File: 80225-02-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-p-chlorophenyl-4-tosyl-2-oxazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 5-p-chlorophenyl-4-tosyl-2-oxazoline(80225-02-1)
• EPA Substance Registry System: 5-p-chlorophenyl-4-tosyl-2-oxazoline(80225-02-1)

Safety Data

• Hazardous Substances Data: 80225-02-1(Hazardous Substances Data)

Upstream product

• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 104-88-1 4-chlorobenzaldehyde 
• 10564-55-3 1-isocyanatomethanesulfonyl-4-methyl-benzene 

Downstream Products

• 1008-94-2 5-(4-chloro-phenyl)-oxazole 

Relevant articles and documents

A Mild and convenient synthesis of 4-tosyl-4,5-dihydrooxazoles

A facile and mild synthesis of 4-tosyl-4,5-dihydrooxazoles is described. The reaction between tosyl methyl isocyanide (TosMIC) and cinnamic or aromatic aldehydes is catalyzed by triethylamine, affording trans-5-styryl- or 5-aryl-4-tosyl-4,5-dihydrooxazole

Synthesis of 2,5-Disubstituted Oxazoles from Aldehydes and N-(Tosylmethyl)imino Synthons. Application to the Synthesis of Pimprinine Analogues

A series of N-(tosylmethyl)imino compounds has been applied to a new base induced, one-operational synthesis of 2,5-disubstituted oxazoles from aromatic aldehydes.For substituent A of the imino compounds, which becomes the 2-substituent in the oxazoles, has been chosen methoxy, methyl and phenyl.The new method has been used also to synthesize seven pimprinine analogues, i.e., 5-(3-indolyl)oxazoles.