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1008-94-2

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1008-94-2 Usage

General Description

5-(4-chlorophenyl) oxazole is an organic chemical featuring a fusion of oxazole, a heterocyclic compound, and chlorophenol groups. It is noteworthy for having a ring structure with varied atoms including carbon, nitrogen, and oxygen, with a chlorine atom attached on the phenyl ring. 5-(4-chlorophenyl) oxazole is mainly involved in scientific studies and laboratory synthesis due to its functional group diversity and heterocyclic nature. Its exact properties such as its boiling point, melting point, and density could vary based on experimental conditions and additional substitutions. Its specific applications or toxicity profiles are typically not standardized and can depend on its detailed chemical configuration and application.

Check Digit Verification of cas no

The CAS Registry Mumber 1008-94-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,0 and 8 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1008-94:
(6*1)+(5*0)+(4*0)+(3*8)+(2*9)+(1*4)=52
52 % 10 = 2
So 1008-94-2 is a valid CAS Registry Number.
InChI:InChI=1/C9H6ClNO/c10-8-3-1-7(2-4-8)9-5-11-6-12-9/h1-6H

1008-94-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-(4-Chlorophenyl)-1,3-oxazole

1.2 Other means of identification

Product number -
Other names Oxazole,5-(4-chlorophenyl)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1008-94-2 SDS

1008-94-2Relevant articles and documents

Cobalt-Catalyzed Cross-Dehydrogenative Coupling Reactions of (Benz)oxazoles with Ethers

Li, Yanrong,Wang, Mengshi,Fan, Wei,Qian, Fen,Li, Guigen,Lu, Hongjian

, p. 11743 - 11750 (2016)

The cobalt-catalyzed cross-dehydrogenative coupling of (benz)oxazoles and ethers is described. Access to some important bioactive heteroaryl ether derivatives was achieved using CoCO3 as an inexpensive catalyst at levels as low as 1.0 mol %. In

Reaction Conditions for the Regiodivergent Direct Arylations at C2- or C5-Positions of Oxazoles using Phosphine-Free Palladium Catalysts

Shi, Xinzhe,Soulé, Jean-Fran?ois,Doucet, Henri

, p. 4748 - 4760 (2019/09/12)

Two sets of reaction conditions for the regiodivergent C2- or C5- direct arylations of oxazole are reported. In both cases, phosphine-free catalysts and inexpensive bases were employed allowing the access to the arylated oxazoles in moderate to high yields. Using Pd(OAc)2/KOAc as catalyst and base, regioselective C5-arylations were observed; whereas, using Pd(acac)2/Cs2CO3 system, the arylation occurred at the C2-position of oxazole. The higher reactivity of C5-H bond of oxazole as compared to the C2-H bond in the presence of Pd(OAc)2/KOAc system is consistent with a concerted metalation deprotonation mechanism; whereas the C2-arylation likely occurs via a simple base deprotonation of the oxazole C2-position. Then, from these C2- or C5-arylated oxazoles, a second palladium-catalyzed direct C?H bond arylation affords 2,5-diaryloxazoles with two different aryl groups. We also applied these sequential arylations to the straightforward synthesis of 2-arylphenanthro[9,10-d]oxazoles via three C?H bond functionalization steps. The Ru-catalyzed C?H arylation of the aryl unit of 2-aryloxazoles is also described. (Figure presented.).

A One-Pot Tandem Approach for the Synthesis of 5-(Het)aryloxazoles from Substituted (Het)aryl Methyl Alcohols and Benzyl Bromides

Vinay Kumar, Koravangala S.,Swaroop, Toreshettahally R.,Rajeev, Narasimhamurthy,Vinayaka, Ajjampura C.,Lingaraju, Gejjalagere S.,Rangappa, Kanchugarakoppal S.,Sadashiva, Maralinganadoddi P.

supporting information, p. 1363 - 1366 (2016/06/01)

A new modified van Leusen strategy has been developed for the synthesis of biologically significant 5-substituted oxazoles by the reaction of (het)aryl methyl alcohols or benzyl bromides as precursors with tosylmethylisocyanide (TosMIC) under basic conditions. This method is efficient, takes place under mild reaction conditions, and is tolerant of various functional groups with high yield.

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