80226-49-9

Basic information

• Product Name: N (2,6-Diamino-4-oxo-5-dihydropyrimidine-5yl)formamid
• Synonyms: N (2,6-Diamino-4-oxo-5-dihydropyrimidine-5yl)formamid
• CAS NO: 80226-49-9
• Molecular Formula: C5H7 N5 O2
• Molecular Weight: 0
• Mol File: 80226-49-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N (2,6-Diamino-4-oxo-5-dihydropyrimidine-5yl)formamid(CAS DataBase Reference)
• NIST Chemistry Reference: N (2,6-Diamino-4-oxo-5-dihydropyrimidine-5yl)formamid(80226-49-9)
• EPA Substance Registry System: N (2,6-Diamino-4-oxo-5-dihydropyrimidine-5yl)formamid(80226-49-9)

Safety Data

• Hazardous Substances Data: 80226-49-9(Hazardous Substances Data)

Upstream product

• 64-18-6 formic acid 
• 1004-75-7 2,5,6-triamino-4-hydroxypyrimidine 
• 2387-48-6 2,4-diamino6-hydroxy-5-nitroso pyrimidine 

Relevant articles and documents

Nitrogen-Doped Carbon Supported Co/Ni Bimetallic Catalyst for Selectively Reductive N-Formylation of Nitroso in Guanine Synthesis

A nitrogen-doped carbon supported Co/Ni bimetallic catalyst 2wt%Co/Ni@NC-700-10 was prepared and found to be efficient in the reductive N-formylation of 2,4-diamino-5-nitroso-6-hydroxypyrimidine (DANHP) to 2,4-diamino-5-formyl-6-hydroxypyrimidine (DAFHP) for the synthesis of guanine. Under optimal conditions, the conversion of DANHP reached up to 95.6% with a DAFHP selectivity of 97.6%. The characterization results revealed that the cobalt/nickel nanoparticles of the catalyst uniformly dispersed and encapsulated in the nitrogen-dopped carbon, and the catalyst has the characters of large surface area, as well as uniform dispersion and small diameters of metal nanoparticles in the form of Co/Ni alloy, which endowed its good catalytic performance in the reaction. Graphical abstract: [Figure not available: see fulltext.]

Process for the preparation of TAHP

The invention relates to an improved process for the catalytic hydrogenation of DAHNP and a new process for preparing 2,4-diamino-5-formylamino-6-hydroxypyrimidine.