80227-48-1Relevant academic research and scientific papers
THE ANAEROBIC DEGRADATION OF DEOXYCHOLIC ACID BY PSEUDOMONAS SP. NCIB 10590
Owen, R.W.,Mason, A.N.,Bilton, R.F.
, p. 421 - 426 (2007/10/02)
The anaerobic metabolism of deoxycholic acid by Pseudomonas sp.NCIB 10590 wsa studied.The metabolic pathway was similar to that operating under aerobic conditions with 12β-hydroxyandrosta-1,4-dien-3,17-dione as the major neutral product and 12α-hydroxy-5β
MICROBIAL DEGRADATION OF DEOXYCHOLIC ACID BY PSEUDOMONAS sp. NCIB 10590. CHARACTERISATION OF PRODUCTS AND A POSTULATED PATHWAY
Bilton, R. F.,Mason, A. N.,Tenneson, M. E.
, p. 2509 - 2514 (2007/10/02)
Minor products in the microbial degradation of deoxychlolic acid are characterised and a metabolic pathway proposed.In a previous publocation we reported the transformation of deoxycholic acid 1 by Pseudomonas sp.NCIB 10590, in a mineral salts medium, to a mixture of neutral and acidic steroids.The major neutral product, 12β-hydroxyandrosta-1,4-dien-3,17-dione 2 and the major acidic product 12α-hydroxypregna-1,4-dien-3-one-20-carboxylic acid 9 were identified.We now report the structures of the minor products and propose a metabolic pathway.
