802287-59-8Relevant academic research and scientific papers
CATHEPSIN PROTEASES INHIBITORS
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Page/Page column 21, (2008/12/05)
The invention provides compounds (I) and pharmaceutical compositions thereof, and more particularly, bicyclic carbamates, which are useful as cathepsin inhibitors, and methods for using such compounds or pharmaceutically acceptable salts thereof, wherein
Bicyclic carbamates as inhibitors of papain-like cathepsin proteases
Epple, Robert,Urbina, Hugo D.,Russo, Ross,Liu, Hong,Mason, Daniel,Bursulaya, Badry,Tumanut, Christine,Li, Jun,Harris, Jennifer L.
, p. 1254 - 1259 (2007/10/03)
A 6-oxa-1-aza-bicyclo[3.2.1]octan-7-one system inhibits the proteolytic activity of several cysteine proteases belonging to the papain family. In vitro mechanistic studies and in silico calculations suggest that the minimal π-overlap between the bridgehea
