694452-80-7

Upstream product

• 80231-40-9 2-iodo-3-quinolinecarboxaldehyde 
• 100-46-9 benzylamine 
• 140-88-5 ethyl acrylate 
• 73568-25-9 2-chloro-3-quinoline carboxaldehyde 

Downstream Products

• 110351-92-3 (R)-4-ethyl-4-hydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H)-dione 
• 7689-03-4 camptothecin 
• 31456-25-4 camptothecin 
• 694452-82-9 3-ethoxycarbonylmethyl-1,3-dihydro-pyrrolo[3,4-b]quinoline-2-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

A synthesis of camptothecin

A total synthesis of camptothecin has been carried out. Central to our synthesis is the intramolecular condensation of a suitably designed ketol, which in turn was obtained from a tricyclic ABC ring synthon. A tandem reductive amination and Michael additi

Synthesis of indolizinoquinolinones through three- and four-component domino Knoevenagel / hetero-Diels–Alder reactions: novel access to (+)-camptothecin

[Figure not available: see fulltext.] The fused heterocyclic indolizinoquinolinone system is a key structural feature of several highly bioactive alkaloids, including camptothecin. Camptothecin has been efficiently obtained by a three- or four-component domino Knoevenagel / hetero-Diels–Alder reaction of aldehyde, Meldrum's acid, and enol ether in the presence or absence of alcohol, followed by reductive cleavage of the amine protecting group. The obtained products were further transformed along several different routes leading to camptothecin.