80234-65-7

Basic information

• Product Name: (8S,15S)-DIHETE
• Synonyms: (8S,15S)-dihydroxy-(5Z,9E,11Z,13E)-*eicosatetraen;(8S,15S)-DIHYDROXY-(5Z,9E,11Z,13E)-EICOS ATETRAENOI;8(S),15(S)-DiHETE (Z, E, Z, E);(8S,15S)-DIHETE;(8S,15S)-DIHYDROXY-(5Z,9E,11Z,13E)-EICOSATETRAENOIC ACID;8(S),15(S)-DIHYDROXYEICOSA-5Z,9E,11Z,13E-TETRAENOIC ACID
• CAS NO: 80234-65-7
• Molecular Formula: C20H32O4
• Molecular Weight: 336.47
• Mol File: 80234-65-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: −20°C
• CAS DataBase Reference: (8S,15S)-DIHETE(CAS DataBase Reference)
• NIST Chemistry Reference: (8S,15S)-DIHETE(80234-65-7)
• EPA Substance Registry System: (8S,15S)-DIHETE(80234-65-7)

Safety Data

• Hazard Codes: F,Xi
• Statements: 11-36/37/38
• Safety Statements: 16-26-36
• RIDADR: UN 1170 3/PG 2
• WGK Germany: 1
• Hazardous Substances Data: 80234-65-7(Hazardous Substances Data)

Usage

Description

8(S),15(S)-DiHETE is formed when 15(S)-HETE is subjected to further oxidation by 15-LO. It causes eosinophil chemotaxis with an ED50 value of 1.5 μM but is not chemotactic for neutrophils. 8(S),15(S)-DiHETE antagonizes the hyperalgesic activity of 8(R),15(S)-DiHETE and LTB4 in the rat hind paw pain model.

Uses

8(S),15(S)-DiHETE (Z, E, Z, E) is a novel dioxygenation product of arachidonic acid.

Upstream product

• 506-32-1 all cis 5,8,11,14-eicosatetraenoic acid 
• 93292-49-0 methyl 8(S)-<(tert-butyldiphenylsilyl)oxy>-9-oxo-5(Z)-nonenoate 
• 93292-50-3 (Z)-(R)-8-(tert-Butyl-diphenyl-silanyloxy)-9-oxo-non-5-enoic acid methyl ester 
• 93292-62-7 (2R,3S)-3-(tert-Butyl-diphenyl-silanyloxy)-octane-1,2-diol 
• 93292-63-8 (S)-2-(tert-butyldiphenylsilyloxy)heptanal 
• 17814-85-6 (4-carboxybutyl)triphenylphosphonium bromide 
• 76964-62-0 (5Z,9E,11Z,13E)-(8S,15S)-8,15-Dihydroxy-icosa-5,9,11,13-tetraenoic acid methyl ester 
• 93292-61-6 tert-Butyl-[(S)-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-hexyloxy]-diphenyl-silane 
• 93292-72-9 (5Z,9E,11E,13Z)-(8R,15S)-8,15-Dihydroxy-icosa-5,9,11,13-tetraenoic acid methyl ester 
• 93292-45-6 methyl 8(S)-<(tert-butyldiphenylsilyl)oxy>-9,10-(isopropylidenedioxy)-5(Z)-decenoate 
• 93292-43-4 (Z)-(S)-8-(tert-Butyl-diphenyl-silanyloxy)-8-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-oct-5-enoic acid 
• 93292-47-8 methyl 8(S)-<(tert-butyldiphenylsilyl)oxy>-9,10-dihydroxy-5(Z)-decenoate 
• 93292-51-4 methyl 8(S)-<(tert-butyldiphenylsilyl)oxy>-11-oxo-5(Z),9(E)-undecadienoate 
• 93381-40-9 (5Z,9E,11Z,13E)-(8S,15S)-8,15-Bis-(tert-butyl-diphenyl-silanyloxy)-icosa-5,9,11,13-tetraenoic acid methyl ester 

Relevant articles and documents

Total Synthesis of 5(S),15(S)-Dihydroxy-6,13-trans-8,11-cis-eicosatetraenoic Acid (5,15-DiHETE) and 8(S),15(S)-Dihydroxy-5,11-cis-9,13-trans-eicosatetraenoic Acid (8,15-DiHETE): Two Novel Metabolites of Arachidonic Acid

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The total syntheses of several 8,15 dihydroxy arachidonic acid derivatives (8,15, LTB's)

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