93292-62-7Relevant academic research and scientific papers
A chemoenzymatic asymmetric synthesis of (9S,12S,13S)- and (9S,12RS,13S)-pinellic acids
Sharma, Anubha,Mahato, Seema,Chattopadhyay, Subrata
scheme or table, p. 4986 - 4988 (2009/12/03)
A brief and facile synthesis of the title compounds has been developed by using an efficient lipase-catalyzed acylation and a chiral template-directed diastereoselective alkylation for incorporating the stereogenic centres. A cross-metathesis was employed to get the required E-olefin geometry.
TOTAL SYNTHESIS OF LIPOXINS A4 AND B4 FROM D-ISOASCORBIC ACID
Gravier-Pelletier, C.,Dumas, J.,Merrer, Y. Le,Depezay, J. C.
, p. 1165 - 1168 (2007/10/02)
A total convergent synthesis of lipoxins A4 and B4 has been carried out via four optically pure α-hydroxy and α,β-dihydroxyaldehydes, obtained from D-isoascorbic acid as a single starting material.Connection by a six carbons unit uses Wittig-type reaction
CHIRAL α-HYDROXY- AND α,β-DIHYDROXY-ALDEHYDES FROM D-ISOASCORBIC AND L-ASCORBIC ACIDS. USEFUL PRECURSORS FOR THE SYNTHESIS OF FATTY ACID METABOLITES.
Merrer, Y. Le,Gravier-Pelletier, C.,Dumas, J.,Depezay, J. C.
, p. 1002 - 1006 (2007/10/02)
The four possible stereoisomers of α,β-dihydroxyaldehydes, useful building blocks for the synthesis of fatty acids metabolites, are synthesized via epoxy-tetrols derived from D-isoascorbic and L-ascorbic acids.The general method we develop allows the synthesis of chiral α-hydroxyaldehydes as well.
