80242-22-4

Usage

Chemical structure

A pyrrole ring with a carbonitrile group at the 3-position and an acetyl group at the 5-position

Physical state

Pale yellow solid at room temperature

Use

Building block in chemical synthesis, used in the production of pharmaceuticals, agrochemicals, and other fine chemicals

Unique property

The presence of the acetyl group attached to the pyrrole ring gives 1H-Pyrrole-3-carbonitrile, 5-acetyl- (9CI) unique properties and makes it a valuable intermediate in the synthesis of various organic compounds.

Upstream product

• 1189-71-5 isocyanate de chlorosulfonyle 
• 35302-72-8 pyrrol-2-yl trichloromethyl ketone 
• 1072-83-9 2-Acetylpyrrole 

Relevant academic research and scientific papers

Indolinone derivatives and their use in treating disease-states such as cancer

Indolinone derivatives, such as compounds of the formula (I): wherein A, m, n, R1, R2, R3, R5 and R6 are described herein, are disclosed herein as being useful in treating mammal having disease-states alleviated by the inhibition of PDK-1 activity.

Pyrrole chemistry. XXIII. The cyanation of substituted pyrroles with chlorosulfonyl isocyanate (CSI). New syntheses of pyrrole-3-carbonitriles

Chlorosulfonyl isocyanate (CSI) reacts not only with pyrrole itself but with pyrroles having powerful electron-withdrawing groups in the 2-position.Suitable choice of electron-withdrawing groups allows selective 4-substitution of the pyrrole ring.The N-chlorosulfonyl amides formed are readily converted to the corresponding nitriles.The procedure has been used to provide syntheses of pyrrole-3-carbonitrile and its 1-methyl homologue.