80254-72-4Relevant academic research and scientific papers
METHODS OF USING INDAZOLE-3-CARBOXAMIDES AND THEIR USE AS WNT/B-CATENIN SIGNALING PATHWAY INHIBITORS
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Paragraph 0303; 0304, (2018/05/16)
This disclosure features the use of one or more indazole-3-carboxamide compounds or salts or analogs thereof, in the treatment of one or more diseases or conditions independently selected from the group consisting of a tendinopathy, dermatitis, psoriasis, morphea, ichthyosis, Raynaud's syndrome, and Darier's disease; and/or for promoting wound healing. The methods include administering to a subject (e.g., a subject in need thereof) a therapeutically effective amount of one or more indazole-3-carboxamide compounds or salts or analogs thereof as described anywhere herein.
INDAZOLE-3-CARBOXAMIDES AND THEIR USE AS WNT/B-CATENIN SIGNALING PATHWAY INHIBITORS
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Paragraph 00271, (2013/03/28)
lndazole-3-carboxamide compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an indazole-3- carboxamide compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.
F-NMR-spectroscopy for the identification of photo products generated from aromatic iodo compounds - IV
Kelm, J.,Strauss, K.
, p. 689 - 692 (2007/10/02)
The investigation demonstrates the analytical power of F-NMR spectroscopy for the identification of isomeric substituted fluorobiphenyls.The biphenyls are formed by u.v. irradiation of iodobenzenes in aromatic solvents.A special procedure for the identification is outlined and tendencies of the results-chemical shifts and relative rates for the production of isomers-are discussed in consideration of electronic and steric substituent effects.
