80258-99-7

Usage

Chemical class

Acridine carboxylic acids

Explanation

1-CHLORO-9,10-DIHYDRO-9-OXO-4-ACRIDINECARBOXYLIC ACID belongs to the class of acridine carboxylic acids, which are organic compounds derived from acridine.
2. Derivative of acridine

Explanation

This chemical compound is a derivative of acridine, meaning it is structurally related to acridine and has similar properties.
3. Chlorine atom at the 1-position

Explanation

The compound contains a chlorine atom attached to the 1-position of the acridine ring, which influences its chemical properties and reactivity.
4. Carboxylic acid group at the 4-position

Explanation

A carboxylic acid group (-COOH) is present at the 4-position of the acridine ring, contributing to the compound's acidity and potential for forming salts or esters.
5. Potential biological activities

Explanation

1-CHLORO-9,10-DIHYDRO-9-OXO-4-ACRIDINECARBOXYLIC ACID has been studied for its possible biological activities, such as antimicrobial and antitumor properties.
6. Applications in pharmaceuticals

Explanation

Due to its potential biological activities, 1-CHLORO-9,10-DIHYDRO-9-OXO-4-ACRIDINECARBOXYLIC ACID may be used in the development of pharmaceuticals for treating various diseases and conditions.
7. Applications in agrochemicals

Explanation

The compound may also have uses in the agrochemical industry, potentially serving as a pesticide, herbicide, or fungicide.
8. Versatile chemical

Explanation

1-CHLORO-9,10-DIHYDRO-9-OXO-4-ACRIDINECARBOXYLIC ACID is a versatile chemical with potential applications in various fields, including medicine, agriculture, and research.

InChI:InChI=1/C14H8ClNO3/c15-9-6-5-8(14(18)19)12-11(9)13(17)7-3-1-2-4-10(7)16-12/h1-6H,(H,16,17)(H,18,19)

Upstream product

• 50-84-0 2,4 dichlorobenzoic acid 
• 100038-84-4 2-(2-Carboxy-phenylamino)-4-chloro-benzoic acid methyl ester 
• 118-92-3 anthranilic acid 
• 1488-42-2 Diphenyliodonium-2-carboxylate 
• 5900-58-3 2-amino-4-chloro-benzoic acid methyl ester 
• 63329-53-3 lobenzarit 

Downstream Products

• 106626-67-9 1-Chloro-acridine-4-carboxylic acid (2-dimethylamino-ethyl)-amide 

Relevant academic research and scientific papers

A nitrogen hetero-cycloalkyl amino quinacridineone-4-amide compound and its preparation method and application

The invention provides an azo-heteroaromatic cycloalkylaminoacridone-4-amide compound which is shown in a formula I or a formula II as shown in the specification, as well as a preparation method and application thereof. In the formula I and the formula II

Molecular design, synthesis and biological research of novel pyridyl acridones as potent DNA-binding and apoptosis-inducing agents

A series of novel pyridyl acridone derivatives comprised of a pseudo-five-cyclic system to extend the π-conjugated acridone chromophore, were designed and synthesized as potent DNA binding antitumor compounds. Most synthesized compounds displayed good act

Potential Antitumor Agents. 46. Structure-Activity Relationships for Acridine Monosubstituted Derivatives of the Antitumor Agent N--9-aminoacridine-4-carboxamide

A series of monosubstituted derivatives of the new antitumor agent N--9-aminoacridine-4-carboxamide has been prepared, bearing methyl, methoxy, and chloro groups at available acridine positions.The physicochemical properties and an

Synthesis of Substituted 9-Oxo-9,10-dihydroacridine-4-carboxylic Acids. I. Factors Affecting the Direction of Ring Closure of Substituted N-(2-Carboxyphenylamino)benzoic Acids

The cyclodehydration of 16 substituted N-(2-carboxyphenylamino)benzoic acids to substituted 9-oxo-9,10-dihydroacridine-4-carboxylic acids with conc.H2SO4, POCl3 and ethyl polyphosphate (epp) has been studied by h.p.l.c.Direction of ring closure can be qua

Potential antitumor agents. 38. 3-Substituted 5-carboxamido derivatives of amsacrine

The synthesis and biological evaluation of a series of 3-substituted 5-carboxamido derivatives of amsacrine (m-AMSA) are described. This series was developed as the result of previous quantitative structure-activity relationship (QSAR) studies of the antitumor activity of 9-anilinoacridine derivatives. In agreement with these studies, this class of compounds, possessing a variety of small nonpolar groups at the 3-position, together with very hydrophilic carboxamido groups at the 5-position, have high in vivo activity against animal leukemia models.

Potential Antitumor Agents. 36. Quanitative Relationships between Experimental Antitumor Activity, Toxicity, and Structure for the General Class of 9-Anilinoacridine Antitumor Agents

Quantitative relationships (QSAR) have been derived between antileukemic (L1210) activity and agent physicochemical properties for 509 tumor-active members of the general class of 9-anilinoacridines.One member of this class is the clinical agent m-AMSA (NSC 249992).Agent hydrophobicity proved a significant but not a dominant influence on in vivo potency.The electronic properties of substituent groups proved important, but the most significant effects on drug potency were shown by the steric influence of groups placed at various positions on the 9-anilinoacridine skeleton.The results are entirely consistent with the physiologically important step in the action of these compounds being their binding to double-stranded DNA by intercalation of the acridine chromophore between the base pairs and positioning of the anilino group in the minor groove, as previously suggested.An equation was also derived for the acute toxicities of 643 derivatives of 9-anilinoacridine.This equation took a somewhat similar form to the one modeling antileukemia potency, emphasizing the usual fairly close relationship between potency and acute toxicity for antitumor agents in general.This study demonstrated the power of QSAR techniques to structure very large amounts of biological data and to allow the extraction of useful information from bearing on the possible site of action of the compounds concerned.