80267-19-2Relevant academic research and scientific papers
Pharmaceutical compositions
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, (2008/06/13)
The compounds of the general Formula I STR1 (wherein R1 and R2 may be the same or different and each stands for hydrogen, hydroxy, C1-6 alkoxy, C1-6 alkoxy-C1-6 alkoxy, C2-6 alkenyloxy or p
Synthesis and antimycobacterial effects of some lipophilic substituted 2,4-diamino-5-benzylpyrimidines
Hachtel,Haller,Seydel
, p. 1778 - 1783 (2007/10/02)
2,4-Diamino-5-benzylpyrimidines 1-23 with lipophilic substitution in the benzylic moiety were synthesized by the morpholino-anilino-procedure. Their effects against various mycobacteria were verified by MIC (minimum inhibitory concentration) in whole cells and I50-measurements in whole cell and cell-free systems. Especially the substances 7-12 are strong inhibitors of some atypical mycobacterial strains which are sometimes associated with tuberculosis in the elderly and with AIDS. They might be promising candidates for therapy.
