80277-06-1

Usage

Uses

Used in Organic Synthesis:
7-Chlorobenzo[c][1,2,5]oxadiazol-4-amine is used as a building block for the synthesis of various biologically active molecules due to its unique structure and functional groups.
Used in Medicinal Chemistry:
7-Chlorobenzo[c][1,2,5]oxadiazol-4-amine is used as a potential anticancer agent, as it has been studied for its ability to target and inhibit the growth of cancer cells.
Used in Material Science:
7-Chlorobenzo[c][1,2,5]oxadiazol-4-amine is used as a precursor for the synthesis of advanced materials with unique properties, such as fluorescent probes for biological imaging.
Used in Biological Imaging:
7-Chlorobenzo[c][1,2,5]oxadiazol-4-amine is used as a component in the development of fluorescent probes, which are essential tools for visualizing and studying biological processes at the molecular level.

Upstream product

• 10199-89-0 NBD chloride 
• 7439-89-6 iron 

Relevant academic research and scientific papers

Rational design of NIR fluorescence probes for sensitive detection of viscosity in living cells

Developing near-infrared (NIR) fluorescence probes for detection of intracellular viscosity is still sufficiently challenging. In this work, three kinds of D-A-D type naphthyl and 2,1,3?benzoxadiazol hybrid NIR dyes functionalized with amino (NY1), N?methylamino (NY2) and N,N?dimethylamino (NY3) groups for intracellular micro-viscosity detection were designed and synthesized. All the probes exhibited very weak NIR emission in low viscosity environment and obvious fluorescence enhancement with the increased viscosity. Different substituent groups had a high impact on the photophysical properties and response sensitive of the probes to viscosity. The structure-property relationships were systematic investigated. The results showed that stronger electron-donating ability and larger steric effect of N,N?dimethylamino led to a narrower energy gap and more sensitive to viscosity environment. Therefore, NY3 exhibited higher signal noise ratio for viscosity detection and was successfully applied for imaging the changes of intracellular micro-viscosity. This work provides an efficient way to design powerful NIR fluorescence probes for viscosity detection.

For viscosity detecting near-infrared fluorescence probe and its preparation and use

The invention relates to a method for viscosity detecting near-infrared fluorescence probe and its preparation and use, which belongs to the detection field. The material of the invention is cheap, simple and convenient operation, mild reaction conditions, low production cost, convenient industrial a compound with larger Stokes displacement can be used for measuring the viscosity of the near-infrared probe, and by mass spectrometry, nuclear magnetic resonance hydrogen and carbon spectrum characterization means such as nuclear magnetic resonance to the target compound to carry out the precise structure characterization. Such probe can be applied to human health/disease detection and diagnosis, the use of these probe can detect changes in the viscosity of the cell, thus can be achieved to the disease early warning. The probe has a better chemical stability, biological compatibility and selective. Laser confocal imaging experiments show that the probe has a better cell permeability, toxic to cells and organisms, can realize the cell level detecting and indicating the viscosity of the viscosity change, can further application disease early detection research.

Small Molecule Agonists and Antagonists of NR2F6 Activity in Humans

The present technology is directed to modulators of nuclear receptor activity, specifically to the modulation of NR2F6 activity and NR2F6 utilizing compounds, and the immune modulation and modulation of cancer stem cell activity through administration of

A Small Push-Pull Fluorophore for Turn-on Fluorescence

A new class of push-pull dyes is reported based on the structures of benzoxa- and benzothiadiazole heterocycles. This new class of dyes displays red-shifted wavelengths of emission and greater sensitivity to polarity and hydrogen bonding solvents relative to previously known derivatives.

DRUGS FOR INHIBITING P38 AND USES THEREOF

The present invention relates to compounds with a benzoxadiazolyl amine structure which are capable of inhibiting the activation or the biological activity of p38 mitogen-activated protein kinase (MAPK) and the use thereof in the treatment of a disease th

DRUGS FOR INHIBITING P38 AND USES THEREOF

The present invention relates to compounds with a benzoxadiazolyl amine structure which are capable of inhibiting the activation or the biological activity of p38 mitogen-activated protein kinase (MAPK) and the use thereof in the treatment of a disease th

METHOD FOR THE PREPARATION OF FUSED HETEROCYCLIC SUCCINIMIDE COMPOUNDS AND ANALOGS THEREOF

Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.

Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function

Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.