80279-25-0

Usage

Uses

Used in Pharmaceutical Industry:
11-Epitilivalline is used as a cytotoxic agent for its potential application in cancer treatment. Specifically, it has shown effectiveness against mouse leukemia L1210 cells, suggesting that it may have broader applications in targeting and combating various types of cancer cells.
Given the limited information provided, further research and development would be necessary to explore the full potential of 11-Epitilivalline in different applications and industries. However, its demonstrated cytotoxicity towards mouse leukemia cells indicates a promising direction for its use in the pharmaceutical industry, particularly in cancer treatment and research.

Upstream product

• 80279-24-9 tilivalline 
• 24115-89-7 3-benzyloxy-2-nitrobenzoic acid 
• 82354-29-8 (2S)-2-pyrrolidinyl-3'-indolyl ketone 
• 82354-31-2 (2S)-N-(3-benzyloxy-2-nitrobenzoyl)-2-pyrrolidinyl-3'-indolyl ketone 

Relevant academic research and scientific papers

Reaction pathway for epimerization of tilivalline

A series of the reaction pathway for the epimerization of tilivalline has been revealed in detail at the AM1 semi-empirical level.

Epimerization of Tilivalline

Epimerization of tilivalline (1) at the C11-position occurred by treatment with zinc chloride to give a mixture of 1 and its 11-epimer (epi-1) in a ratio 83 : 17.The computational chemical analysis of the thermodynamic stability of 1 and epi-1 through MM3(92) also revealed the energetic preference of 1 and the calculated equilibrium ratio of 1 and epi-1 was consistent with the experimental results.The torsional and bending angle parameters around the amide bond were determined.

TILIVALLINE, A NEW PYRROLOBENZODIAZEPINE METABOLITE FROM KLEBSIELLA.

From Klebsiella pneumoniae (+)(11S,11aS)-(1,2,3,10,11,11a-hexahydro-9-hydroxy-11-(3'-indolyl)-5H-pyrrolobenzodiazepin-5-one (1) has been isolated for which the name tilivalline is suggested.Structure elucidation and synthesis are reported.