80283-44-9Relevant academic research and scientific papers
Metal-free approach for hindered amide-bond formation with hypervalent iodine(iii) reagents: application to hindered peptide synthesis
Lee, Hyo-Jun,Huang, Xiao,Sakaki, Shigeyoshi,Maruoka, Keiji
, p. 848 - 855 (2021)
A new bio-inspired approach is reported for amide and peptide synthesis using α-amino esters that possess a potential activating group (PAG) at the ester residue. To activate the ester functionality under mild metal-free conditions, we exploited the facile dearomatization of phenols with hypervalent iodine(iii) reagents. Using a pyridine-hydrogen fluoride complex, highly reactive acyl fluoride intermediates can be successfully generated, thereby allowing for the smooth formation of sterically hindered amides and peptides from bulky amines and α-amino esters, respectively.
ELECTROCHEMICAL TRANSACYLATIONS: A MILD SYNTHESIS OF ESTERS
Johnson, Richard W.,Bednarski, M. D.,O' Leary, B. F.,Grover, E. R.
, p. 3715 - 3718 (2007/10/02)
Esters can be synthesized by electrochemically oxidizing hydroquinone carboxylates in the presence of alcohols.High yields are obtained in acidic or basic solutions and at low temperatures.
