80289-15-2Relevant academic research and scientific papers
Direct N-Alkylation and Kemp Elimination Reactions of 1-Sulfonyl-1H-Indazoles
Tang, Meng,Chu, Bingjie,Chang, Xiaowei
, p. 2109 - 2116 (2018/07/31)
The reactions of 1-sulfonyl-1H-indazoles under basic conditions are discussed, and the direct N-alkylation and Kemp elimination reactions of these compounds are reported. A series of 2-(p-tosylamino)benzonitriles and N-alkyl indazoles were prepared in good yields. Moreover, the 2-(p-tosylamino)benzonitriles could be transformed into a diverse range of important derivatives in a one-pot reaction. This method was successfully applied to the total syntheses of quindolinone and cryptolepinone; quindolinone was prepared in a one-pot reaction from 1-sulfonyl-1H-indazole.
Microwave-assisted reductive cyclization: An easy entry to the indoloquinolines and spiro[2H-indole-2,3′-oxindole]
Parvatkar, Prakash T.,Majik, Mahesh S.
, p. 22481 - 22486 (2014/06/23)
Synthesis of two linear indoloquinolines i.e. 6H-indolo[2,3-b]quinoline & 11-hydroxy-10H-indolo[3,2-b]quinoline, and spiro[2H-indole-2,3′- oxindole] from a common intermediate, (2-nitrophenyl)methylidene-dihydro- indolone derivative is described using microwave-mediated reductive cyclization as the key step. This journal is the Partner Organisations 2014.
Investigation of the reaction of N-acetylindoxyl with substituted anilines. Synthesis of derivatives of indolo[3,2-b]quinolines
Tugusheva,Ryabova,Solov'eva,Anisimova,Granik
, p. 885 - 893 (2007/10/03)
1-Acetyl-2,3-dihydrospiro[indolo-3, 2′-(1′,2′,3′, 4′-tetrahydroquinazolin-4′-one) was obtained from the reaction with anthranilamide, and 3-(2′-acetylaminophenyl)quinoxalin-2-one from the reaction with o-phenylenediamine, along with the normal products of the condensation of N-acetylindoxyl with substituted anilines. Derivatives of indolo[3,2-b]quinoline were synthesized from the obtained condensation products.
Anti-malaria active 10H-indolo[3,2-b]quinoline-11-yl-amines. Part 2: Chloroquine analogues
Gorlitzer,Stockmann,Walter
, p. 105 - 111 (2007/10/02)
The quinolones 1b and 1c react with tosylisocyanate to yield the tosylamino quinolines 2b and 2c, while 1a under the same conditions gives the carbamate 5. Decarboxylation of 5 affords 2a. The mono and bis alkylated products 3 and 6 are received from 2 b.
