802920-02-1

Basic information

• Product Name: Benzene, [(1,1-difluoro-5-phenoxypentyl)sulfonyl]-
• CAS NO: 802920-02-1
• Molecular Formula: C17H18F2O3S
• Molecular Weight: 340.391
• Mol File: 802920-02-1.mol

Chemical Properties

• CAS DataBase Reference: Benzene, [(1,1-difluoro-5-phenoxypentyl)sulfonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, [(1,1-difluoro-5-phenoxypentyl)sulfonyl]-(802920-02-1)
• EPA Substance Registry System: Benzene, [(1,1-difluoro-5-phenoxypentyl)sulfonyl]-(802920-02-1)

Safety Data

• Hazardous Substances Data: 802920-02-1(Hazardous Substances Data)

Upstream product

• 20549-72-8 4-phenoxybutyl iodide 
• 1535-65-5 difluoromethyl phenyl sulfone 

Downstream Products

• 802920-09-8 1,1-difluoro-5-phenoxypentane 

Relevant articles and documents

Nucleophilic difluoromethylation of primary alkyl halides using difluoromethyl phenyl sulfone as a difluoromethyl anion equivalent

(Chemical Equation Presented) A facile and efficient nucleophilic difluoromethylation of primary alkyl halides has been disclosed through a novel nucleophilic substitution-reductive desulfonylation strategy, using difluoromethyl phenyl sulfone as a difluo

NUCLEOPHILIC SUBSTITUTION REACTIONS OF DIFLUOROMETHYL PHENYL SULFONE WITH ALKYL HALIDES LEADING TO THE FACILE SYNTHESIS OF TERMINAL 1,1-DIFLUORO-1-ALKENES AND DIFLUOROMETHYLALKANES

(Benzenesulfonyl)difluoromethyl anion, in situ generated from difluoromethyl phenyl sulfone and a base, was found to easily undergo nucleophilic substitution reactions (SN2 with primary alkyl halides, elemental halogens, and perfluoroalkyl halides with good selectivity. The formed (Benzenesulfonyl) difluoromethylalkanes are useful intermediates for the facile preparation of 1,1-difluoro-1alkenes and difluoromethylalkanes. Thus, difluoromethyl phenyl sulfone acts as both “CF2=” and CF2H” synthons.

Difluoromethyl phenyl sulfone, a difluoromethylidene equivalent: Use in the synthesis of 1,1-difluoro-1-alkenes

A nucleophilic substitution-elimination reaction strategy in which difluoromethyl phenyl sulfone is used as a selective difluoromethylidene equivalent allows the facile synthesis of 1,1-difluoro-1-alkenes from primary alkyl halides (see scheme).