80295-40-5

Usage

Uses

Used in Immunological Research:
COMPLEMENT C2-DEPLETED SERUM, HUMAN is used as a research tool for investigating the mechanisms of complement activation and the role of C2 in the immune response. This serum is particularly valuable for studying how bacterial pathogens, such as Pseudomonas aeruginosa, evade detection by the complement system through the degradation of C2 by enzymes like alkaline protease (AprA).
Used in Pathogen Evasion Studies:
In the field of microbiology, COMPLEMENT C2-DEPLETED SERUM, HUMAN is used as an experimental medium to explore how certain bacteria, such as Pseudomonas aeruginosa, interfere with the classical and lectin pathways of the complement system. This research is essential for understanding the strategies employed by pathogens to avoid immune detection and for developing new therapeutic approaches to counteract these mechanisms.
Used in Infection Risk Assessment:
COMPLEMENT C2-DEPLETED SERUM, HUMAN is utilized in research to assess the increased risk of infection associated with C2 deficiency, such as the heightened susceptibility to Streptococcus pyogenes. This application aids in understanding the consequences of impaired phagocytosis and neutrophil-dependent killing, which are critical for effective immune defense against invading pathogens.
Overall, COMPLEMENT C2-DEPLETED SERUM, HUMAN serves as a vital resource in advancing our knowledge of the human immune system, particularly in the context of complement activation and pathogen evasion strategies. Its applications in various research fields contribute to the development of novel therapeutics and preventive measures against infectious diseases.

Biochem/physiol Actions

Heritable complement C2 deficiency can manifest as a number of severe dermatological disorders, including discoid lupus erythematosus, idiopathic atrophoderma, and dermatomyositis.