802983-60-4

Upstream product

• 802983-59-1 {1-[6,6-bis-(4-fluoro-phenyl)-hexanoyl]-pyrrolidin-3-ylmethyl}-carbamic acid tert-butyl ester 
• 149366-79-0 3-(RS)-(N-tert-butoxycarbonylaminomethyl)pyrrolidine 

Relevant academic research and scientific papers

Structure-activity relationships of trimethoxybenzyl piperazine N-type calcium channel inhibitors

We previously reported the small organic N-type calcium channel blocker NP078585 that while efficacious in animal models for pain, exhibited modest L-type calcium channel selectivity and substantial off-target inhibition against the hERG potassium channel

3-AMINOMETHYL-PYRROLIDINES AS N-TYPE CALCIUM CHANNEL BLOCKERS

The invention relates to compounds that are derivatives of 3-aminomethyl-pyrrolidine of the formulas: wherein: Y is (X2)1A or (X1)mCR4A2; W is CR4 or N; R1-R4 are noninterfering substituents; n is 0-7; 1 and m are independently 0 or 1; X1-X2 are linkers;