83501-15-9

Upstream product

• 35282-97-4 2,3-dibromo-4'-chlorocinnamic acid ethyl ester 
• 104-88-1 4-chlorobenzaldehyde 
• 599-99-5 ethyl tribromoacetate 
• 803-14-5 ethyl 2-bromo-2-(triphenylphosphoranylidene)acetate 

Downstream Products

• 20026-96-4 ethyl 3-(4-chlorophenyl)propiolate 
• 1039341-12-2 (Z)-ethyl 3-(4-chlorophenyl)-3-(1,3-dioxoisoindolin-2-yl)acrylate 
• 42393-39-5 (Z)-2-bromo-3-(4-chlorophenyl)propenoic acid 
• 100281-78-5 (4S,5R)-5-(4-Chloro-phenyl)-3-isopropyl-2-phenyl-4,5-dihydro-3H-imidazole-4-carboxylic acid ethyl ester 
• 100281-78-5 (4S,5S)-5-(4-Chloro-phenyl)-3-isopropyl-2-phenyl-4,5-dihydro-3H-imidazole-4-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Transition metal-free diastereospecific synthesis of (Z)-2-arylidene-2,3-dihydrobenzo[b][1,4]dioxines by reaction of (Z)-1,2-dibromo-3-aryl-2-propenes with catechols

A transition metal-free, diastereospecific reaction between substituted (Z)-1,2-dibromo-3-phenyl-2-propenes and substituted catechols using Cs2CO3 as a base at 140 °C for 18 h delivers exclusively substituted (Z)-2-arylidene-2,3-dihy

Simple and efficient copper-catalyzed approach to 2,4-disubstituted imidazolones

(Figure Presented) Some imidazolone derivatives are biological and pharmaceutical active molecules and the chromophores of the fluorescent proteins. In this communication, a simple and efficient approach to 4-arylidene-2-alkyl-4,5-dihydro-1H-imidazol-5-ones (2,4-disubstituted imidazolones) has been developed, and the protocol uses readily available 2-bromo-3-alkylacrylic acids and amidines as the starting materials without addition of any ligand or additive. The reactions were performed under mild conditions. Therefore, the present method will be of wide application in organic chemistry and medicinal chemistry.

A convenient synthesis and the asymmetric hydrogenation of N-phthaloyl dehydroamino acid esters

(Chemical Equation Presented) A convenient synthetic method was reported for the preparation of N-phthaloyl dehydroamino acid esters from easily accessible vinyl bromides (or vinyl tosylate) and potassium phthalimide. Rh-catalyzed asymmetric hydrogenation

Preparation of α-bromoacrylates: One-pot procedure for the synthesis of conjugated acetylenic carboxylates from aldehydes with Ph3P/ Br3CCO2Et

We have established the optimal conditions for the Wittig reaction for synthesizing α-bromoacrylates with a high selectivity, and developed a simple and efficient one-pot procedure for preparing various conjugated acetylenic carboxylates in moderate to high yields. Georg Thieme Verlag Stuttgart.

Versatile Transformations of α,β-Dibromoesters and Ketones in Basic Media under Microwave Irradiation

Depending on the reaction medium, α,β-dibromoesters under microwave irradiation may selectively lead to α-bromoalk-enes, to alkenes or to (E)-β-bromostyrenes. The corresponding ketones give selectively the α-bromoketones.

α-hypervalent iodine functionalized phosphonium and arsonium ylides and their tandem reaction as umpolung reagents

α-Hypervalent iodine functionalized phosphonium and arsonium ylides 2 can be used as umpolung ylides to react with nucleophiles to give α-heteroatom substituted ylides 4 in good yields. The nucleophilic substitution - Wittig tandem reaction of 2 can occur smoothly to provide an efficient method for the synthesis of (Z)-α-halo-α,β-unsaturated enoates or enones 6, stereoselectively.