123017-47-0

Usage

Uses

Used in Organic Synthesis:
Methyl 2-(N-benzylforMaMido)acetate is used as a reagent for the preparation of various organic compounds, facilitating the synthesis of a wide range of chemical entities.
Used in Pharmaceutical Research:
In the pharmaceutical industry, Methyl 2-(N-benzylforMaMido)acetate is used as a building block for the synthesis of novel drug candidates, contributing to the development of new therapeutic agents.
Used in Chemical Production:
Methyl 2-(N-benzylforMaMido)acetate is employed in the production of specialty chemicals, where its unique properties allow for the creation of specific chemical products that cater to various industrial needs.

Upstream product

• 64-18-6 formic acid 
• 53386-64-4 methyl 2-(benzylamino)acetate 
• 124-38-9 carbon dioxide 
• 100-46-9 benzylamine 
• 67-56-1 methanol 
• 63086-36-2 2-(benzylamino)acetonitrile hydrochloride 

Downstream Products

• 76075-15-5 methyl 1-benzyl-2-mercapto-5-imidazolecarboxylate 
• 73941-33-0 methyl 1-benzyl-1H-imidazole-5-carboxylate 
• 80304-50-3 1-benzyl-5-hydroxymethylimidazole 

Relevant academic research and scientific papers

Effective Formylation of Amines with Carbon Dioxide and Diphenylsilane Catalyzed by Chelating bis(tzNHC) Rhodium Complexes

The reductive formylation of amines using CO2 and hydrosilanes is an attractive method for incorporating CO2 into valuable organic compounds. However, previous systems required either high catalyst loadings or high temperatures to achieve high efficiency, and the substrate scope was mostly limited to simple amines. To address these problems, a series of alkyl bridged chelating bis(NHC) rhodium complexes (NHC=N-heterocyclic carbene) have been synthesized and applied to the reductive formylation of amines using CO2 and Ph2SiH2. A rhodium-based bis(tzNHC) complex (tz=1,2,3-triazol-5-ylidene) was identified to be highly effective at a low catalyst loading and ambient temperature, and a wide substrate scope, including amines with reducible functional groups, were compatible. Beyond the norm: Rhodium complexes bearing a strong electron-donating bis(1,2,3-triazol-5-ylidene) ligand were found to be excellent catalysts for the reductive formylation of amines with CO2 and Ph2SiH2 at ambient temperature. The catalyst system possesses a broad substrate scope which tolerates a variety of reducible functional groups and is suitable for the synthesis of bioactive compounds. Tf=trifuoromethanesulfonyl.

Improved specific synthesis of [1′-15N]- and [3′-15N]L-histidine

Specifically, 15N-enriched L-histidines have been prepared. The labelling methodology involves introduction of labels in its precursor 1-benzyl-5-hydroxy methyl imidazole, which is converted into L-histidine via the Schoellkopf method. The procedure allows the preparation of the intermediates and finally histidine with high 15N enrichment (99%) at each position, in 29% overall yield starting with 15NH4Cl and 56% with KSC15N, respectively. Copyright