80320-16-7Relevant academic research and scientific papers
Important cytotoxic and cytostatic effects of new copper(i)-phosphane compounds with N,N, N,O and N,S bidentate ligands
Morais, Tania S.,Jousseaume, Yann,Piedade, M. Fátima M.,Roma-Rodrigues, Catarina,Fernandes, Alexandra R.,Marques, Fernanda,Villa De Brito, Maria J.,Helena Garcia
, p. 7819 - 7829 (2018)
A family of six phosphane Cu(i) complexes bearing N,N, N,O and N,S bidentate ligands was synthesized. All the compounds were fully characterized by classical analytical and spectroscopic methods, and five of them were also characterized by X-ray diffraction studies. All the compounds exhibit high cytotoxicity against the human breast cancer cell line MCF7 with IC50 values far lower than those found for cisplatin, a current chemotherapeutic in clinical use. Compounds 1 and 3 induce cell cycle arrest in the G2/M phase and cell death by apoptosis. The cytotoxic and cytostatic effects of these compounds on MCF7 cells suggest that they are suitable for further in vivo studies with breast cancer models.
Thermal decomposition and stability in a series of tetrafluorborate copper(I) complexes
Lucca Neto, V. A. de,Mauro, A. E.,Sargentelli, V.,Ionashiro, M.
, p. 235 - 242 (1995)
Tetrafluorborate copper(I) complexes containing acetonitrile, triphenylphosphine, 1,10-phenanthroline,2,2'-bipyridine and 2-quinolinethiol have been prepared in order to study their thermal stabilities as a function of the ligands present. The characterization of the above compound was carried out by elemental analysis and IR spectroscopy. Their thermal behaviour has been investigated and the final products were identified by X-ray powder diagrams.
