80322-70-9

Upstream product

• 21572-32-7 2-chloro-1-phenyl-ethanone oxime 
• 109-92-2 ethyl vinyl ether 
• 14181-72-7 2-bromo-1-phenyl-ethanone oxime 

Downstream Products

• 80322-72-1 3,4-dihydro-2-methoxy-5-phenyl-2H-pyrrole 1-oxide 
• 161362-38-5 (3S,6S)-6-Ethoxy-3-phenyl-[1,2]oxazinane 
• 161362-38-5 (3S,6R)-6-Ethoxy-3-phenyl-[1,2]oxazinane 
• 105623-50-5 2,3-dibenzoyl-6-methoxy-3a-phenyl-3a,4,5,6-tetrahydropyrrolo<1,2-b>isoxazole 

Relevant academic research and scientific papers

Hydrotalcite catalysed [4+2] cycloaddition reactions of nitroso- and azo-alkenes

The generation of nitroso- and azo-alkenes and their [4+2] cycloaddition reactions with furan and ethyl vinyl ether, producing dihydro-1,2-oxazines and tetrahydropyridazines, by the use of catalytic Mg:Al 3:1 hydrotalcite, is described. The absence of an

Acid-catalysed Rearrangement of 3-Acyl-6-alkoxy-5,6-dihydro-4H-1,2-oxazines: a Route to 3-Alkoxypyridine 1-Oxides

6-Alkoxy-5,6-dihydro-4H-1,2-oxazines (2) and (5) have been prepared by the reaction of chloro oximes (1) with enol ethers in the presence of sodium carbonate.The 3-phenyloxazine (2) rearranges to the nitrone (3) in methanolic HCl.In contrast, the 3-acyloxazines (5a-e) are converted into 3-alkoxypyridine 1-oxides (7) in aqueous alcoholic HCl.With HCl in acetic acid the oxazine (5a) is converted into 2-chloromethyl-3-hydroxypuridine hydrochloride (10a); analogous reactions take place with oxazines (5b) and (5d).Possible mechanisms for these reactions are discussed.