80348-54-5 Usage
Derivative of imidazole
A modified version of the imidazole molecule, which is a heterocyclic aromatic organic compound.
Contains a nitro group
A functional group consisting of an oxygen atom double-bonded to a nitrogen atom (-NO2), which can be a source of negative charge in reactions.
Contains a methyl group
A functional group consisting of a single carbon atom bonded to three hydrogen atoms (-CH3), which can provide steric hindrance and electronic effects.
Contains a phenylsulfonyl group
A functional group consisting of a sulfur atom double-bonded to a phenyl ring (C6H5-S-), which can provide additional reactivity and structural diversity.
Building block in organic synthesis
A compound that can be used as a starting material or intermediate in the synthesis of more complex organic molecules.
Used in pharmaceutical research
A compound that is studied for its potential applications in the development of new drugs and therapies.
Potential use in new drug development
The compound's unique structure and properties make it a promising candidate for the development of new drugs, particularly those targeting infectious diseases and cancer.
Interesting candidate for medicinal chemistry and drug design
The compound's structure and properties make it a valuable subject for further investigation in the fields of medicinal chemistry and drug design, potentially leading to the discovery of new therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 80348-54-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,3,4 and 8 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 80348-54:
(7*8)+(6*0)+(5*3)+(4*4)+(3*8)+(2*5)+(1*4)=125
125 % 10 = 5
So 80348-54-5 is a valid CAS Registry Number.
80348-54-5Relevant articles and documents
Synthesis and In-vitro antibacterial activity of 5-substituted 1-methyl-4-nitro-1H-imidazoles
Letafat, Bahram,Emami, Saeed,Aliabadi, Alireza,Mohammadhosseini, Negar,Moshafi, Mohammad Hassan,Asadipour, Ali,Shafiee, Abbas,Foroumadi, Alireza
experimental part, p. 497 - 501 (2009/04/04)
A series of 5-substituted 1-methyl-4-nitro-1H-imidazole derivatives were synthesized and evaluated for in-vitro antibacterial activity against a panel of microorganisms including Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis, Esherichia coli, Klebsiella pneumonia, Entrobacter aerogenes, and Helicobacter pylori using conventional agar dilution method. Among the test compounds, 1-methyl-4-nitro-5-(phenylsulfonyl)-1H-imidazole was the most potent against Gram-positive bacteria, with a MIC value of ≤8 μg/mL. All compounds showed no significant activity against Gram-negative bacteria at concentrations ≤64 μg/mL The MIC values against 15 clinical isolates of H. pylori indicated that compounds 10 and 11 were the most active compounds in this series in terms of inhibiting the growth of H. pylori (MIC = 2 μg/mL). It was also demonstrated that their corresponding activities were four times larger than that of metronidazole.
