80355-07-3Relevant articles and documents
Solid phase synthesis of hydantoins using a carbamate linker and a novel cyclization/cleavage step
Dressman,Spangle,Kaldor
, p. 937 - 940 (1996)
An 800 compound hydantoin library has been constructed using a diverse set of 20 amino acids and over 80 primary amines. Amino acids were attached via their N-termini to hydroxymethyl polystyrene using a carbamate linker. Bound amino acids were converted to their corresponding amides and then cyclized under basic conditions to give hydantoins in high purities.
Chemical Reactions of Cycloalkanespirohydantoins. Part 2. Synthesis of New 4-Hydroxyimidazolidinone N3-Substituted from Cycloalkanespirohydantoins
Salazar, Loreto,Rubido, Julia,Espada, Modesta,Pedregal, Carmen,Trigo, Gregorio,Elguero, Jose
, p. 481 - 485 (2007/10/02)
N3-Substituted hydantoins have been to undergo lithium aluminum hydride reduction (THF, room temperature, 5 hours) to give 4-hydroxy-2-imidazolidinones in good yields.