Solid phase synthesis of hydantoins using a carbamate linker and a novel cyclization/cleavage step

Article abstract of DOI:10.1016/0040-4039(95)02395-X

An 800 compound hydantoin library has been constructed using a diverse set of 20 amino acids and over 80 primary amines. Amino acids were attached via their N-termini to hydroxymethyl polystyrene using a carbamate linker. Bound amino acids were converted to their corresponding amides and then cyclized under basic conditions to give hydantoins in high purities.