80356-44-1

Upstream product

• 32606-02-3 4-hydroxy-1,3-dimethyl-2(1H)-quinolone 
• 3287-99-8 benzylamine hydrochloride 
• 17583-40-3 2-methylaminobenzonitrile 
• 109-99-9 tetrahydrofuran 

Downstream Products

• 32606-02-3 4-hydroxy-1,3-dimethyl-2(1H)-quinolone 

Relevant academic research and scientific papers

Radical Annulation of 2-Cyanoaryl Acrylamides via C=C Double Bond Cleavage: Access to Amino-Substituted 2-Quinolones

A novel annulation of 2-cyanoaryl acrylamides via C=C double bond cleavage has been developed for facile and efficient access to a broad spectrum of functionalized 4-amino-2-quinolones, which are important N-heterocycles. In this transformation, the solvent THF is demonstrated to play a crucial role, and the addition of alkyl radicals to nitrile, 1,5-hydride shift, and cleavage of the C-C bond are involved in the mechanism.