803732-70-9

Basic information

• Product Name: 2-Butynoic acid, 4-(2-fluorophenyl)-4-hydroxy-, ethyl ester
• CAS NO: 803732-70-9
• Molecular Formula: C12H11FO3
• Molecular Weight: 222.216
• Mol File: 803732-70-9.mol

Chemical Properties

• CAS DataBase Reference: 2-Butynoic acid, 4-(2-fluorophenyl)-4-hydroxy-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butynoic acid, 4-(2-fluorophenyl)-4-hydroxy-, ethyl ester(803732-70-9)
• EPA Substance Registry System: 2-Butynoic acid, 4-(2-fluorophenyl)-4-hydroxy-, ethyl ester(803732-70-9)

Safety Data

• Hazardous Substances Data: 803732-70-9(Hazardous Substances Data)

Upstream product

• 446-52-6 2-Fluorobenzaldehyde 
• 623-47-2 propynoic acid ethyl ester 

Downstream Products

• 803732-77-6 (E)-4-(2-Fluoro-phenyl)-4-oxo-but-2-enoic acid ethyl ester 

Relevant articles and documents

Metal-free annulative hydrosulfonation of propiolate esters: synthesis of 4-sulfonates of coumarins and butenolides

An efficient metal-free and cost-effective method for the synthesis of coumarin and butenolide 4-sulfonates (46 examples) has been developed. The reaction involves addition of sulfonic acids to ethyl propiolates followed by lactonization, resulting in direct formation of coumarin and butenolide 4-sulfonates. This methodology has been elaborated to Sonogashira and Suzuki coupling including the synthesis of rac-tolterodine.

A short, novel approach to 2,3,4a,5-tetrahydro-1H-pyrazino[1,2-a] quinoline-4,6-diones

An expeditious route to constrained arylpiperazinones has been developed. The key reaction formed the tricyclic system in one-pot via a 1,4-addition-lactamization-aromatic substitution sequence. Four examples were prepared.