80386-12-5Relevant academic research and scientific papers
Stereoselective Reactions. 14.Efficient Enantioselective Construction of Quaternary Carbon Centers by the Sequential Dialkylation of (S)-γ--γ-butyrolactone. Synthesis of Optically Active β,β-Disubstituted γ-Butyrolactones.
Tomioka, Kiyoshi,Cho, Youn-Sang,Sato, Fuminori,Koga, Kenji
, p. 4094 - 4098 (2007/10/02)
Sequential dialkylation of the lithium enolate, generated from (S)-γ--γ-butyrolactone (1), with two different alkyl halides created chiral quaternary carbon centers with extremely high diastereoface selection.A unique conformation of 1,
HIGHLY STEREOSELECTIVE CONSTRUCTION OF CHIRAL QUATERNARY CARBON: ASYMMETRIC SYNTHESIS OF β,β-DISUBSTITUTED γ-BUTYROLACTONES
Tomioka, Kiyoshi,Cho, Youn-Sang,Sato, Fuminori,Koga, Kenji
, p. 1621 - 1624 (2007/10/02)
Asymmetric synthesis of β,β-disubstituted γ-butyrolactones was carried out in highly stereoselective and predictable way, by means of sequential dialkylation of (S)-γ-trityloxymethyl-γ-butyrolactone followed by lactone carbonyl transposition.Application t
