80403-82-3 Usage
Uses
Used in Neurological Research:
3-Chloro-5-isoxazolepropanoic acid is used as a research tool for studying the function of glutamate receptors in the brain, specifically the AMPA receptors. Its agonistic action at these receptors is crucial for understanding their role in neuronal communication and synaptic plasticity.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 3-Chloro-5-isoxazolepropanoic acid is utilized in the development of potential therapeutic agents targeting neurological disorders. Its interaction with AMPA receptors provides insights into the mechanisms of neuronal excitation and inhibition, which are pivotal in conditions like epilepsy and neurodegenerative diseases.
Used in the Study of Neurological Disorders:
3-Chloro-5-isoxazolepropanoic acid is employed as a research compound to investigate the pathophysiology of neurological disorders. Its ability to modulate AMPA receptor activity aids in exploring the underlying causes of these conditions and in identifying potential therapeutic targets for intervention.
Check Digit Verification of cas no
The CAS Registry Mumber 80403-82-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,4,0 and 3 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 80403-82:
(7*8)+(6*0)+(5*4)+(4*0)+(3*3)+(2*8)+(1*2)=103
103 % 10 = 3
So 80403-82-3 is a valid CAS Registry Number.
InChI:InChI=1/C6H6ClNO3/c7-5-3-4(11-8-5)1-2-6(9)10/h3H,1-2H2,(H,9,10)
80403-82-3Relevant academic research and scientific papers
SYNTHESIS OF 3-HALOISOXAZOLES BY NOVEL OXIDATIVE DEGRADATION OF THE SIDE-CHAIN OF 3-(3-HALO-ISOXAZOL-5-YL) PROPIONIC ACIDS
Lugosi, Peter,Schawartz, Jozsef,Doleschall, Gabor
, p. 3061 - 3066 (2007/10/02)
A novel method for the oxidative degradation of the side-chain of 3-(3-haloisoxazol-5-yl) propionic acids has been developed.The E-3-(3-chloroisoxazol-5-yl) propenoic acid 13a obtained by treatment of the s-triazolo quinazolin-4-ium iodide 11a with PhI(OAc)2 and Bz2O2, respectively, and subsequent hydroxysis, has been used for the synthesis of numerous 3-haloisoxazole derivatives.
