80424-18-6

Basic information

• Product Name: AMARIN
• Synonyms: AMARIN;triphenylimidazoline
• CAS NO: 80424-18-6
• Molecular Formula: C21H20N2
• Molecular Weight: 300.4
• Mol File: 80424-18-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 459.8°C at 760 mmHg
• Flash Point: 286.6°C
• Appearance: /
• Density: 1.099g/cm³
• Vapor Pressure: 1.22E-08mmHg at 25°C
• Refractive Index: 1.602
• CAS DataBase Reference: AMARIN(CAS DataBase Reference)
• NIST Chemistry Reference: AMARIN(80424-18-6)
• EPA Substance Registry System: AMARIN(80424-18-6)

Safety Data

• Hazardous Substances Data: 80424-18-6(Hazardous Substances Data)

Usage

General Description

AMARIN is the brand name for the drug containing the active ingredient omega-3 carboxylic acids. It is used to reduce the risk of heart attack, stroke, and certain types of heart problems in people who have heart disease. The medication works by lowering triglyceride levels in the blood, which helps to prevent the buildup of fatty deposits in the arteries. AMARIN is typically prescribed as an adjunct to a healthy diet and lifestyle changes for the treatment of high triglycerides. Common side effects may include muscle pain, joint pain, and flu-like symptoms. It is important for patients to discuss potential risks and benefits with their healthcare provider before starting treatment with AMARIN.

InChI:InChI=1/C21H20N2/c1-4-10-16(11-5-1)19-20(17-12-6-2-7-13-17)23-21(22-19)18-14-8-3-9-15-18/h1-15,19-23H

Upstream product

• 35132-20-8 (R,R)-1,2-diphenylethylenediamine 
• 100-52-7 benzaldehyde 
• 29841-69-8 (S,S)-1,2-diphenyl-1,2-diaminoethane 
• 573-33-1 amarine 
• 92-29-5 (E,E)-1,3,5-triphenyl-2,4-diazapenta-1,4-diene 
• 951-87-1 rac-1,2-diphenylethylene-1,2-diamine 
• 33722-46-2 isoamarine 

Relevant articles and documents

Chiral Bis(imidazolidine)iodobenzene (I-Bidine) Organocatalyst for Thiochromane Synthesis Using an Asymmetric Michael/Henry Reaction

Bis(imidazolidine)iodobenzene (I-Bidine) was designed as an organocatalyst based on previously reported imidazolidine- or oxazolidine-containing chiral metal catalysts. I-Bidine showed catalytic activity for the Michael/Henry reaction of thiosalicyl aldeh

One-pot synthesis of imidazolines from aldehydes: detailed study about solvents and substrates

Imidazolines were prepared in one-pot operation from aldehydes and diamines through oxidation of aminal intermediates by NBS. This method could be applied to various aromatic and aliphatic aldehydes and N-nonsubstituted and N-monosubstituted 1,2-diamines. Furthermore, it was found that CH2Cl2 could be altered to TBME, a more environmentally friendly solvent, in the reaction using N-nonsubstituted 1,2-diamines. The reaction conditions were very mild and chemoselective.

A simplified synthesis of (±)-1,2-Diphenyl-1,2-diaminoethane (1) from benzaldehyde and ammonia. Revision of the structures of the long-known intermediates 'hydrobenzamide' and 'amarine'

A new pathway for the simple, stereocontrolled and economical synthesis of (±)-1 from benzaldehyde is described. The structures of two intermediates (Scheme 1) have been revised to those shown in Scheme 2.