80426-66-0

Usage

General Description

2(1H)-Pyrimidinethione, 4,6-dimethyl-1-(4-methylphenyl)-, also known as cloconazole, is a chemical compound that belongs to the family of pyrimidines. It is commonly used as an antifungal agent in the treatment of various fungal infections in humans and animals. Cloconazole works by inhibiting the growth of fungi and disrupting the synthesis of their cell membranes. It has broad-spectrum antifungal activity and is effective against a wide range of fungi, including dermatophytes, yeasts, and molds. Additionally, it has been found to have low toxicity and minimal adverse effects, making it a valuable option for the treatment of fungal infections.

Upstream product

• 622-52-6 p-methylphenylthiourea 
• 123-54-6 acetylacetone 
• 74152-12-8 4,6-Dimethyl-1-p-tolyl-1H-pyrimidin-2-one 

Downstream Products

• 127251-75-6 4,6-Dimethyl-1-p-tolyl-1H-pyrimidine-2-selone 
• 80426-62-6 4,6-dimethyl-2-(p-toluidino)pyrimidine 1-oxide 
• 81261-68-9 4,6-dimethyl-N-(4-methylphenyl)-2-pyrimidinamine 
• 85960-88-9 1,2-dihydro-4,6-dimethyl-1-(p-tolyl)pyrimidine 

Relevant academic research and scientific papers

INTRODUCTION OF SELENIUM TO HETEROCYCLIC COMPOUNDS. PART V. SYNTHESIS PF 2-PYRIMIDINESELENONES FROM 2-PYRIMIDINETHIONES

The earlier described method of introduction of selenium to the five-membered heterocyclic ring was applied to synthesize the six-membered heterocyclic ring containing an exocyclic atom of selenium.Ten new derivatives of 2-pyrimidineselenone have been obtained from methylation products of appropriate derivatives of 2-pyrimidinethione treated with the HSe- ion.The structure of the obtained compounds has been confirmed by spectral data.The contribution of and bond vibrations in the IR spectrum is discussed.

AN IMPROVED CONVERSION OF 1,4,6-TRISUBSTITUTED 2(1H)-PYRIMIDINONES INTO THE CORRESPONDING THIONES

1,4,6-Trisubstituted 2(1H)-pyrimidinones (2a-j) are easily converted into the corresponding thiones (3a-j) in high yields by reacting with 2,4-bis(p-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide (1).Further, other diazines, e.g., 2-methyl-6-phe