80427-20-9

Basic information

• Product Name: 7,12-DIOXASPIRO(5,6)DODECANE-3-ONE
• Synonyms: 7,12-DIOXA-SPIRO[5.6]DODECAN-3-ONE;7,12-DIOXASPIRO(5,6)DODECANE-3-ONE
• CAS NO: 80427-20-9
• Molecular Formula: C₁₀H₁₆O₃
• Molecular Weight: 184.23
• Mol File: 80427-20-9.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7,12-DIOXASPIRO(5,6)DODECANE-3-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 7,12-DIOXASPIRO(5,6)DODECANE-3-ONE(80427-20-9)
• EPA Substance Registry System: 7,12-DIOXASPIRO(5,6)DODECANE-3-ONE(80427-20-9)

Safety Data

• Hazardous Substances Data: 80427-20-9(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 48, p. 129, 1983 DOI: 10.1021/jo00149a028

Upstream product

• 110-63-4 Butane-1,4-diol 
• 637-88-7 1,4-Cyclohexanedione 

Downstream Products

• 264271-53-6 C₂₇H₃₃NO₆ 
• 940939-78-6 C₂₂H₃₀O₄ 
• 940939-77-5 C₂₄H₃₄O₅ 
• 83928-82-9 4-[1'-cyano-1'-(ethoxycarbonyl)methylene]cyclohexanone 
• 83928-81-8 2-(4-Oxo-cyclohexylidene)-malononitrile 
• 153618-52-1 3-{(R)-2-Methyl-3-[(E)-(R)-1-phenyl-ethylimino]-7,12-dioxa-spiro[5.6]dodec-2-yl}-propionic acid methyl ester 

Relevant articles and documents

Aryl-cycloalkyl[b]pyrrole derivatives

Aryl-cyclopenta- and arylcyclohexa[b]pyrrole derivatives are provided having the structure STR1 wherein n is 1 or 2; X is --OR1 or --NR2 R3 wherein R1 is H, lower alkyl, cycloalkyl, aryl, aralkyl or cycloalkylalkyl, and R2 and R3 may be the same or different and are H, lower alkyl, cycloalkyl, aryl, aralkyl or cycloalkylalkyl; Y is --OR4 or --NR5 R6 wherein R4 is H or lower alkyl, and R5 and R6 are the same or different and are H or lower alkyl; and Z is aryl. These compounds are useful in inhibiting the 5-lipoxygenation of arachadonic acid in RBL-1 cells and preventing leukotriene formation in macrophages and as such are useful as antiallergy agents and in treating inflammation and psoriasis.