80427-25-4

Basic information

• Product Name: Propionic acid 4-methoxy-3-propionyl-phenyl ester
• Synonyms: Propionic acid 4-methoxy-3-propionyl-phenyl ester
• CAS NO: 80427-25-4
• Molecular Weight: 236.268
• Mol File: 80427-25-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Propionic acid 4-methoxy-3-propionyl-phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propionic acid 4-methoxy-3-propionyl-phenyl ester(80427-25-4)
• EPA Substance Registry System: Propionic acid 4-methoxy-3-propionyl-phenyl ester(80427-25-4)

Safety Data

• Hazardous Substances Data: 80427-25-4(Hazardous Substances Data)

Upstream product

• 13098-94-7 Propansaeure-(4-methoxyphenyl)ester 
• 79-03-8 propionyl chloride 

Downstream Products

• 80427-31-2 1-(5-Hydroxy-2-methoxy-phenyl)-propan-1-one 

Relevant articles and documents

Studies on the Friedel-Crafts Reaction. XVI, Preparation of Isomeric 2-Acyl- and 3-Acyl-4-methoxy Phenols

Acylation of 4-methoxy phenol according to Friedel and Crafts, as well as the rearrangement of its esters according to Fries lead always to 2-acyl-4-methoxy phenols or to their demethylated compounds.The unknown 3-acyl-4-methoxyphenols were prepared in two steps: First, the ester is acylated with the corresponding acyl chloride and SnCl4 in nitromethane.In the second step the resulting ketoesters are hydrolysed.This is a general method.The yields of meta-acylphenols are between 40 and 90percent.The isomeric 2-acyl-4-methoxyphenols which were partly unknown or accessible only in low yields have also been prepared for comparative spectral studies (UV, IR, NMR, MS) of ortho- and meta-acylphenols. - Keywords: Friedel-Crafts acylation; Fries rearrangement; Ketoesters; Spectral data