80427-93-6

Basic information

• Product Name: 6-butanoyl-3-methyl-1,3-benzoxazol-2(3H)-one
• CAS NO: 80427-93-6
• Molecular Formula: C₁₂H₁₃NO₃
• Molecular Weight: 219.2365
• Mol File: 80427-93-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 356°C at 760 mmHg
• Flash Point: 169.1°C
• Density: 1.206g/cm³
• Vapor Pressure: 3E-05mmHg at 25°C
• Refractive Index: 1.557
• CAS DataBase Reference: 6-butanoyl-3-methyl-1,3-benzoxazol-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-butanoyl-3-methyl-1,3-benzoxazol-2(3H)-one(80427-93-6)
• EPA Substance Registry System: 6-butanoyl-3-methyl-1,3-benzoxazol-2(3H)-one(80427-93-6)

Safety Data

• Hazardous Substances Data: 80427-93-6(Hazardous Substances Data)

Upstream product

• 106-31-0 butanoic acid anhydride 
• 21892-80-8 3-methylbenzo[d]oxazol-2(3H)-one 
• 107-92-6 butyric acid 

Downstream Products

• 123172-48-5 1-(3-Hydroxy-4-methylamino-phenyl)-butan-1-one 
• 116337-73-6 7-Butyryl-4-methyl-4H-benzo[1,4]oxazin-3-one 
• 116337-74-7 7-Butyryl-2,4-dimethyl-4H-benzo[1,4]oxazin-3-one 
• 80427-86-7 6-crotonyl-3-methylbenzoxazolinone 
• 80427-89-0 2,3-dihydro-3,5-dimethyl-2,7-dioxo-cyclopentabenzoxazole 
• 116337-83-8 2,2,4-Trimethyl-7-(2-methylene-butyryl)-4H-benzo[1,4]oxazin-3-one 
• 116337-81-6 7-<2-methylenebutanoyl>-4-methyl-2H-1,4-benzoxazin-3(4H)-one 
• 116337-82-7 2,4-Dimethyl-7-(2-methylene-butyryl)-4H-benzo[1,4]oxazin-3-one 
• 135420-23-4 7-Butyryl-4-methyl-2-propyl-4H-benzo[1,4]oxazin-3-one 
• 135420-39-2 7-<2-(ethylthiomethyl)-butyryl>-4-methyl-2,3-dihydro-benzoxazin-<1,4>-3-one 
• 135420-30-3 4-Methyl-7-(2-methylene-butyryl)-2-propyl-4H-benzo[1,4]oxazin-3-one 
• 135420-38-1 7-<2-(4-morpholinomethyl)-butyryl>-4-methyl-2,3-dihydro-benzoxazin-<1,4>-3-one hydrochloride 

Relevant articles and documents

A Convenient and Efficient Method for the Preparation of 6-Acyl-2(3H)-benzoxazolones

Benzoxazolinone derivatives have been found to exhibit various pharmacological properties and 6-acyl-2(3H)-benzoxazolones are considered as key starting materials for the preparation of these compounds.Reported here are the optimal conditions for a regioselective acylation at the 6-position of the benzoxazolinone ring.A general method leading to the expected products in excellent yields consists in using a mixture of aluminum chloride-dimethylformamide as catalyst and acid anhydrides or chlorides as acylating agents.

Acyl-7 dihydro-2,3 benzoxazin-1,4 ones-3 et proprietes normolipemiantes

7-Acyl-2,3-dihydro-1,4-benzoxazin-3-ones and normolipemic properties.Fibrates are still among the most widely used drugs for the treatment of dyslipoproteinemia. 7-Acyl-2,3-dihydro-1,4-benzoxazin-3-ones (Fig.1B) can be considered as conformationally restrained analogues of fibrates, such as fenofibrate.These compounds have been prepared and studied for their normolipemic activity particularly on plasma cholesterol, triglyceride and high density lipoprotein (HDL) cholesterol levels.Hepatotoxicity and mutagenicity have also been evaluated.Some of them show an interesting activity, quite comparable to fenofibrate, and are devoid of hepatotoxicity. hyperlipidemia / hypocholesterolemic drugs / fibrates / 7-acyl-1,4-benzoxazin-3-ones