80427-89-0Relevant articles and documents
Synthesis of 1,11-dihydro-2H-[1,3]oxazolo[4′,5′:5,6]indeno[1,2- b]quinolin-2-ones with potential topoisomerase I inhibitory activity
Delot, Marc,Carato, Pascal,Furman, Christophe,Lemoine, Amelie,Lebegue, Nicolas,Berthelot, Pascal,Yous, Said
scheme or table, p. 3819 - 3822 (2010/03/03)
A series of 1,11-dihydro-2,11-[1,3]oxazolo[4′,5′:5,6]indeno[1, 2-b]quinolin-2-ones were prepared by means of Friedlaender condensations. The starting materials for the preparations were commercial substituted-2- aminoacetophenones and various 5,6-dihydro-2H-indeno[5,6-d][l,3]oxazole-2,7(3H)- diones that were synthesized from 2(3H)-benzoxazolones or their N-methyl analogues. Thieme Verlag Stuttgart.
Condensation of 3-Methylbenzoxazolinone with α,β-Unsaturated Acids
Merdji, B.,Lesieur, D.,Lespagnol, C.,Barbry, D.,Couturier, D.
, p. 1223 - 1227 (2007/10/02)
The reaction between 3-methylbenzoxazolinone and some unsaturated acids in PPA leads to mixtures of compounds, depending on the acid: 6-crotonyl-(or cinnamoyl)-3-methylbenzoxazolinones, 2,3-dihydro-2,5-(or 2,7)dioxo-3-methylcyclopentabenzoxazoles and 6-(3-oxo-indanyl)-3-methylbenzoxazolinones.The structure of the products was established by 13C and 1H nmr spectroscopy and (or) by independent synthesis.Possible mechanisms of the reaction are discussed; when competition is possible as in the last step of the cyclization, the benzene ring shows a higher reactivity than the aromatic nucleus of the benzoxazolinone: the contrary is observed when the benzene ring is p-chloro-substituted.