80428-88-2

Basic information

• Product Name: 3-(4-m-tolyl-piperazino)-propionic acid ethyl ester
• Synonyms: 3-(4-m-tolyl-piperazino)-propionic acid ethyl ester
• CAS NO: 80428-88-2
• Molecular Weight: 276.379
• Mol File: 80428-88-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(4-m-tolyl-piperazino)-propionic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-m-tolyl-piperazino)-propionic acid ethyl ester(80428-88-2)
• EPA Substance Registry System: 3-(4-m-tolyl-piperazino)-propionic acid ethyl ester(80428-88-2)

Safety Data

• Hazardous Substances Data: 80428-88-2(Hazardous Substances Data)

Usage

Chemical compound

3-(4-m-tolyl-piperazino)-propionic acid ethyl ester

Family

Piperazine

Uses

Antihistamine and anticholinergic agent
Derivative of phenothiazine

Reported effects

Sedative and antipsychotic

Mechanism of action

Blocks acetylcholine in the brain

Medical applications

Allergies, motion sickness, excessive acetylcholine activity

Form

Ethyl ester for stability and bioavailability

Upstream product

• 41186-03-2 1-(3-Methylphenyl)piperazine 
• 140-88-5 ethyl acrylate 

Downstream Products

• 7511-73-1 1-(3-hydroxy-n-propyl)-4-(3-methylphenyl)piperazine 

Relevant articles and documents

N-Aryl-N-phenoxy-alkyl-piperazine compounds useful in decreasing intracranial pressure

A piperazine derivative of the formula: STR1 wherein R1 is hydrogen, alkyl (C1-8), alkyl (C1-4)-sulfonyl or an acyl group of the formula: R3 CO--(wherein R3 is hydrogen, alkyl (C1-7), halogenoalkyl (C1-4), alkoxy (C1-4)-carbonyl-alkyl (C1-4), cycloalkyl (C3-6), alkenyl (C2-5), alkoxy (C1-4), amino, alkyl (C1-4)-amino or anilino), R2 is hydrogen, alkyl (C1-4), alkoxy (C1-4)-carbonyl-alkyl (C1-4), carboxy-alkyl (C1-4), alkenyl (C2-5) or alkyl (C1-4)-sulfonyl, or R1 and R2 are combined together to form succinyl group, Ring A is phenyl, alkyl (C1-4)-phenyl or halogenophenyl, and n is an integer of 2 to 6, or a pharmaceutically acceptable acid addition salt thereof. The piperazine derivative (I) has an intracranial pressure-lowering activity. Said derivative also has a depressing effect on central nervous system.