80429-40-9

Upstream product

• 80436-23-3 5-Bromo-1-(1-methylethyl)-2-[2-[4-(3-methoxyphenyl)-1-piperazinyl]ethyl]-1H-naphth[1,2-d]imidazole 
• 5467-58-3 1-bromo-4-methoxynaphthalene 
• 80429-47-6 4-bromo-1-methoxy-2-nitronaphthalene 
• 110545-41-0 4-bromo-N-(1-methylethyl)-2-nitro-1-naphthylamine 
• 110545-42-1 3-chloro-N-(1-methylethyl)-N-(4-bromo-2-nitro-1-naphth)propionamide 
• 2216-69-5 1-Methoxynaphthalene 

Downstream Products

• 80429-41-0 1-Isopropyl-2-{2-[4-(3-methoxy-phenyl)-piperazin-1-yl]-ethyl}-1H-naphtho[1,2-d]imidazole; compound with 3-carboxy-3-hydroxy-pentanedioic acid 

Relevant academic research and scientific papers

Anti-hypertensives: 1-alkyl-2-arylpiperazinoethyl-1H-naphthimidazoles

L 15848 (8b citrate) is a new anti-hypertensive agent belonging to the class of 1-alkyl-2-aminoethylnaphthimidazoles.It lowers blood pressure in spontaneously hypertensive rats (50 mg/kg, p.o.) and in conscious normotensive and renal hypertensive d

Use of some 2-[2-[4-phenyl-1-piperazinyl]ethyl]-1H-naphth-[1,2-D]imidazole derivatives and their pharmaceutically acceptable salts in the treatment of cardiovascular diseases

The present invention is directed to a new pharmacological use of some known naphthoimidazole derivatives. More particularly, the compounds of the invention are 2-[2-(4-phenyl-1-piperazinyl)ethyl]-1H-naphtho[1,2-d]imidazoles of formula STR1 wherein R is selected from methyl and 1-methylethyl and R1 is selected from hydrogen, chloro, methoxy and trifluoromethyl and the pharmaceutically acceptable acid addition salts thereof and possess antihypertensive activity.