80445-36-9Relevant articles and documents
A milk lactone perfume continuous compound into method (by machine translation)
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Paragraph 0045; 0053; 0054; 0068; 0069, (2019/05/08)
The invention belongs to the technical field of synthetic perfume, and in particular relates to a milk lactone perfume continuous compound into a method, including the role of the alkali under the condition of the aldol reaction, then by hydrogenation reaction, Baeyer - Villiger oxidation, acid continuous hydrolysis, dehydrating and gets milk lactone perfume; the aldol condensation reactions include: part of the as a footing of a cyclohexanone with a alkali mixing, heating processing, the rest [...] butyraldehyde mixture of cyclohexanone with, side drop edge added stirring, and after dropping to continue stirring, thermal insulation reaction-butyraldehyde content to 1% following the end of the reaction; static divider separating the oil, collected and recycled water; collecting oil layer after washing the processing and then transferred to the distillating still distillation recovery excessive cyclohexanone mechanically, the collection of the condensation product of the pan bottom; the invention by adding cyclohexanone in a different way, improving the yield of the aldol condensation reaction; and, of the present invention under the conditions of reaction temperature, can step from an aldol condensation product. (by machine translation)
Synthetic method of epsilon-decalactone perfume
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Paragraph 0062; 0069-0073; 0074; 0082-0086, (2019/05/15)
The invention belongs to the technical field of perfume synthesis, and particularly relates to a synthetic method of epsilon-decalactone perfume. The synthetic method comprises the following steps: (1) mixing an alkaline solution with a part of cyclohexanone, then dropwise adding a mixture of n-butyraldehyde and the rest of cyclohexanone into the mixture, carrying out stirring, and carrying out heat preservation for a reaction; (2) standing the reactants in the step (1), collecting a water layer, collecting an oil layer, and washing the oil layer with water to obtain a condensed product 2-butenyl cyclohexanone crude product; (3) carrying out distilling to recover cyclohexanone to obtain 2-butenyl cyclohexanone; (4) carrying out a hydrogenation reaction; (5) collecting a liquid-phase intermediate product 2-butyl cyclohexanone crude product, and carrying out distilling to obtain 2-butyl cyclohexanone; (6) carrying out an oxidation reaction; and (7) carrying out distilling purification toobtain the epsilon-decalactone perfume product. According to the invention, the cyclohexanone is added into the reaction system in different ways, the excess cyclohexanone is used as a reaction solvent through a stirring dripping technology, and the cyclohexanone is reused after being recycled, so that separation and purification processes of the reaction solvent are reduced, and a high reactionyield is ensured.
Enantioselective synthesis of ε-lactones by lipase-catalyzed resolution
Shimotori, Yasutaka,Aoyama, Masakazu,Tsukasa, Hidetaka,Miyakoshi, Tetsuo
, p. 1061 - 1075 (2012/07/28)
Synthesis of optically active ε-dodecalactone (1) by lipase-catalyzed enantioselective acylation with racemic N-alkyl-6-hydroxydodecanamide (rac-2) as a substrate was attempted. Lipase PS-catalyzed acetylation using rac-2 progressed efficiently, and both
