804511-38-4

Upstream product

• 556025-54-8 (R)-1-(2-furyl)-2-(methylamino)ethanol 
• 672326-09-9 N-(4-chlorobenzyl)-2-(chloromethyl)-4-oxo-7-(3-(tetrahydro-2H-pyran-2-yloxy)propyl)-4,7-dihydrothieno[2,3-b]-pyridine-5-carboxamide 
• 158397-53-6 3-furyloxirane 
• 139683-93-5 (R)-2-amino-1-(furan-2-yl)ethanol 
• 556025-79-7 (5R)-3-methyl-5-(2-furyl)-2-oxazolidinone 
• 110-87-2 3,4-dihydro-2H-pyran 
• 556025-49-1 N-methyl-1-(3-furyl)-2-aminoethanol 
• 52103-12-5 3-iodopropyl tetrahydro-2H-pyran-2-yl ether 
• 672326-07-7 N-(4-chlorobenzyl)-2-(hydroxymethyl)-4-oxo-7-(3-(tetrahydro-2H-pyran-2-yloxy)propyl)-4,7-dihydrothieno[2,3-b]-pyridine-5-carboxamide 

Relevant academic research and scientific papers

2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases

A novel series of 2-aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides have been identified as potent antivirals against human herpesviruses. These compounds demonstrate broad-spectrum inhibition of the herpesvirus polymerases HCMV, HSV-1, EBV, and VZV with high specificity compared to human DNA polymerases.

HETEROARYL-ETHANOLAMINE DERIVATIVES AS ANTIVIRAL AGENTS

The present invention provides a compound of formula as described herein, which are useful as antiviral agents, in particular, as agents against viruses of the herpes family.