804550-59-2Relevant academic research and scientific papers
(3- ((QUINAZOLIN-4-YL) AMINO )-1H-PYRAZOL-1-YL) ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS AURORA KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER
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, (2008/06/13)
Quinazoline derivatives of formula (I) for use in the treatment of proliferative diseases such as cancer and in the preparation of medicaments for use in the treatment of proliferative diseases, and to processes for their preparation, as well as pharmaceutical compositions containing, them as active ingredient. X is O or NR 6 ;R 5 is aryl or heteroaryl optionally substituted by 1, 2 or 3 substituents independently selected from halo, hydroxy, cyano, nitro, amino,C 1-4 alkylamino, bis(C1-4 alkyl)amino, C 1-4 alkyl, C 2-4 alkenyl,C 2-4 alkynyl, C 1-4 alkoxy, C(O)NHR17 , NHC(0)R 18 and S(O) p R 19where p is 0,1 or 2;The other substituents are as defined in claim 1.
