804551-13-1

Basic information

• Product Name: 2H-Pyran, tetrahydro-2-methyl-6-[(1R,2R)-2-nitro-1-phenylpropoxy]-, (2S,6R)-
• CAS NO: 804551-13-1
• Molecular Formula: C15H21NO4
• Molecular Weight: 279.336
• Mol File: 804551-13-1.mol

Chemical Properties

• CAS DataBase Reference: 2H-Pyran, tetrahydro-2-methyl-6-[(1R,2R)-2-nitro-1-phenylpropoxy]-, (2S,6R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Pyran, tetrahydro-2-methyl-6-[(1R,2R)-2-nitro-1-phenylpropoxy]-, (2S,6R)-(804551-13-1)
• EPA Substance Registry System: 2H-Pyran, tetrahydro-2-methyl-6-[(1R,2R)-2-nitro-1-phenylpropoxy]-, (2S,6R)-(804551-13-1)

Safety Data

• Hazardous Substances Data: 804551-13-1(Hazardous Substances Data)

Upstream product

• 705-60-2 1-phenyl-2-nitroprop-1-ene 
• 302342-47-8 2-hydroxy-6-methyltetrahydropyran 

Downstream Products

• 152547-74-5 (2-hydroxy-1-methyl-2-phenyl-ethyl)-carbamic acid tert-butyl ester 
• 804551-21-1 [1-methyl-2-(6-methyl-tetrahydro-pyran-2-yloxy)-2-phenyl-ethyl]-carbamic acid tert-butyl ester 

Relevant articles and documents

Highly stereoselective oxy-Michael additions to α,β- disubstituted nitro olefins: Asymmetric synthesis of pseudo-norephedrine derivatives and THP protected α-hydroxy ketones

The "naked" anion of (S)-6-methyl delta lactol undergoes efficient oxy-Michael addition to α,β-disubstituted nitro olefins to give the THP* protected Henry products with excellent (95→98% de) stereocontrol at the β-position and moderate (up to 3:1) stereo

PRODUCTION OF OXY-MICHAEL ADDUCTS

The invention provides a method of producing an oxy-Michael adduct comprising allowing a Michael acceptor to react with an alkoxide of an alcohol of formula R0H having a chiral centre at the hydroxy carbon, in the presence of a multidentate ligand. The