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Upstream product

• 626-05-1 2,6-Dibromopyridine 
• 62150-34-9 1-n-hexyl-4-iodobenzene 
• 34160-40-2 6-bromo-2-pyridinecarbaldehyde 
• 762262-22-6 2-bromo-6-(4-hexyl-phenylethynyl)-pyridine 
• 183438-97-3 6-ethynylpyridine-2-carboxaldehyde 
• 445468-65-5 6-(trimethylsilyl)ethynyl-2-bromopyridine 
• 445468-63-3 2-ethynyl-6-methylpyridine 

Relevant academic research and scientific papers

Double elimination protocol for access to pyridine-containing arylene-ethynylenes

The arylene-ethynylene arrays involving pyridine were constructed successfully by taking advantage of double elimination reaction of β-substituted sulfones (sulfoximines) which are easily accessible from arylmethyl sulfones (sulfoximines) and aromatic aldehydes. This protocol was utilized for synthesis of an enantiopure arylene-ethynylene framework bearing a binaphthyl stereogenic core.

Double elimination protocol for the synthesis of arylene ethynylenes containing heteroaromatic rings

The double elimination reaction of β-substituted sulfones offers a versatile strategy for synthesis of arylene ethynylene kits containing heteroaromatic rings. A sequence of aldol reaction between α-sulfonyl carbanion and aldehyde, trapping the resulting aldolate to give β-substituted sulfone, and double elimination of this intermediate can be integrated in one pot. This protocol allows thiophene, pyridine, and ferrocene units to be accommodated in phenylene ethynylene arrays.