804555-76-8Relevant articles and documents
Double elimination protocol for access to pyridine-containing arylene-ethynylenes
Orita, Akihiro,Nakano, Takehiko,Yokoyama, Taisaku,Babu, Govindarajulu,Otera, Junzo
, p. 1298 - 1299 (2004)
The arylene-ethynylene arrays involving pyridine were constructed successfully by taking advantage of double elimination reaction of β-substituted sulfones (sulfoximines) which are easily accessible from arylmethyl sulfones (sulfoximines) and aromatic aldehydes. This protocol was utilized for synthesis of an enantiopure arylene-ethynylene framework bearing a binaphthyl stereogenic core.
Double elimination protocol for the synthesis of arylene ethynylenes containing heteroaromatic rings
Orita, Akihiro,Ye, Fangguo,Babu, Govindarajulu,Ikemoto, Tomohiro,Otera, Junzo
, p. 716 - 727 (2007/10/03)
The double elimination reaction of β-substituted sulfones offers a versatile strategy for synthesis of arylene ethynylene kits containing heteroaromatic rings. A sequence of aldol reaction between α-sulfonyl carbanion and aldehyde, trapping the resulting aldolate to give β-substituted sulfone, and double elimination of this intermediate can be integrated in one pot. This protocol allows thiophene, pyridine, and ferrocene units to be accommodated in phenylene ethynylene arrays.