804561-63-5Relevant articles and documents
Design, Synthesis, and Characterization of a Series of Cytochrome P 450 3A-Activated Prodrugs (HepDirect Prodrugs) Useful for Targeting Phosph(on)ate-Based Drugs to the Liver
Erion, Mark D.,Reddy, K. Raja,Boyer, Serge H.,Matelich, Michael C.,Gomez-Galeno, Jorge,Lemus, Robert H.,Ugarkar, Bheemarao G.,Colby, Timothy J.,Schanzer, Juergen,Van Poelje, Paul D.
, p. 5154 - 5163 (2007/10/03)
A new class of phosphate and phosphonate prodrugs, called HepDirect prodrugs, is described that combines properties of rapid liver cleavage with high plasma and tissue stability to achieve increased drug levels in the liver. The prodrugs are substituted c