804560-96-1Relevant articles and documents
Design, Synthesis, and Sustained-Release Property of 1,3-Cyclic Propanyl Phosphate Ester of 18β-Glycyrrhetinic Acid
Sun, Weizhi,Peng, Weibing,Li, Guoqiang,Jiang, Tao
, p. 206 - 211 (2012/02/01)
A new class of potential prodrugs, 1,3-cyclic propanyl phosphate esters of 18β-glycyrrhetic acid, was designed and synthesized through the key reaction of 18β-glycyrrhetic acid with 1,3-cyclic propanyl phosphate ester catalysed by lithium diisopropylamide
Pradefovir: A prodrug that targets adefovir to the liver for the treatment of hepatitis B
Reddy, K. Raja,Matelich, Michael C.,Ugarkar, Bheemarao G.,Gómez-Galeno, Jorge E.,DaRe, Jay,Ollis, Kristin,Sun, Zhili,Craigo, William,Colby, Timothy J.,Fujitaki, James M.,Boyer, Serge H.,Van Poelje, Paul D.,Erion, Mark D.
, p. 666 - 676 (2008/09/19)
Adefovir dipivoxil, a marketed drug for the treatment of hepatitis B, is dosed at submaximally efficacious doses because of renal toxicity. In an effort to improve the therapeutic index of adefovir, 1-aryl-1,3-propanyl prodrugs were synthesized with the r
Design, Synthesis, and Characterization of a Series of Cytochrome P 450 3A-Activated Prodrugs (HepDirect Prodrugs) Useful for Targeting Phosph(on)ate-Based Drugs to the Liver
Erion, Mark D.,Reddy, K. Raja,Boyer, Serge H.,Matelich, Michael C.,Gomez-Galeno, Jorge,Lemus, Robert H.,Ugarkar, Bheemarao G.,Colby, Timothy J.,Schanzer, Juergen,Van Poelje, Paul D.
, p. 5154 - 5163 (2007/10/03)
A new class of phosphate and phosphonate prodrugs, called HepDirect prodrugs, is described that combines properties of rapid liver cleavage with high plasma and tissue stability to achieve increased drug levels in the liver. The prodrugs are substituted c