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Usage

Uses

Used in Pharmaceutical Industry:
2-(3-Hydroxy-Phenyl)-Thiazolidine-4-Carboxylic Acid is used as a pharmaceutical precursor for the development of new drugs due to its potential anti-inflammatory, antibacterial, and antiviral properties. Its carboxylic acid group can improve drug solubility and act as a prodrug, while the hydroxy-phenyl group may contribute to antioxidant or radical scavenging properties, enhancing the therapeutic effects of the resulting drug formulations.
Used in Drug Formulation:
2-(3-Hydroxy-Phenyl)-Thiazolidine-4-Carboxylic Acid is used as a solubility enhancer in drug formulations. The carboxylic acid group can improve the solubility of poorly water-soluble drugs, facilitating their absorption and bioavailability, which is crucial for the effectiveness of many pharmaceuticals.
Used in Antioxidant Applications:
2-(3-Hydroxy-Phenyl)-Thiazolidine-4-Carboxylic Acid is used as an antioxidant agent. The hydroxy-phenyl group may contribute to its antioxidant properties, which can be beneficial in preventing oxidative stress and related diseases, as well as in the preservation of pharmaceutical products by protecting them from degradation caused by oxidation.
Used in Research and Development:
2-(3-Hydroxy-Phenyl)-Thiazolidine-4-Carboxylic Acid is used as a research compound for exploring its potential pharmacological uses. Further investigation into its properties and mechanisms of action could lead to the discovery of new therapeutic applications and the development of innovative drugs for various medical conditions.

InChI:InChI=1/C10H11NO3S/c12-7-3-1-2-6(4-7)9-11-8(5-15-9)10(13)14/h1-4,8-9,11-12H,5H2,(H,13,14)

Upstream product

• 52-90-4 L-Cysteine 
• 100-83-4 meta-hydroxybenzaldehyde 
• 52-89-1 l-cysteine hydrochloride 

Relevant academic research and scientific papers

Synthesis of (4R)-2-(3-hydroxyphenyl)thiazolidine-4-carboxylic acid substituted phthalocyanines: Anticancer activity on different cancer cell lines and molecular docking studies

In this study, firstly, (4R)-2-(3-hydroxyphenyl)thiazolidine-4-carboxylic acid (1) and (4R)-2-(3-(3,4-dicyanophenoxy)phenyl)thiazolidine-4-carboxylic acid (2) were prepared. Then, the novel type metallophthalocyanines (ZnPc (3), CuPc (4), and CoPc (5)) be

Conformational analysis, spectral and catalytic properties of 1,3-thiazolidines, ligands for acetophenone hydrosilylation with diphenylsilane

2-Aryl- and 2-furyl-4-carboxy-1,3-thiazolidines were synthesized. Their spectral properties were studied, and conformational analysis was performed. It was shown that they exist in solution as an equilibrium of neutral and zwitter-ion forms. The influence

Discovery of 2-arylthiazolidine-4-carboxylic acid amides as a new class of cytotoxic agents for prostate cancer

To improve the selectivity and antiproliferative activity of previously reported serine amide phosphates (SAPs), we designed a new series of 4-thiazolidinone amides, in which the 4-thiazolidinone moiety was introduced as a phosphate mimic. However, these 4-thiazolidinone derivatives demonstrated less cytotoxicity in prostate cancer cells despite improved selectivity over RH7777 cells. To further optimize the thiazolidinone analogues in terms of cytotoxicity and selectivity, we made closely related structural modifications, which led us to the discovery of a new class of 2-arylthiazolidine-4-carboxylic acid amides. These compounds were potent cytotoxic agents with IC50 values in the low micromolar concentration range and demonstrated enhanced selectivity in receptor-negative cells compared to SAPs and 4-thiazolidinone amides.

Synthesis and Chiroptical Properties of N-Acetyl-2-aryl-4-thiazolidinecarboxylic Acids

(4R)-2-Aryl-4-thiazolidinecarboxylic acids 3, derived from aromatic aldehydes 1 and L-cysteine (2), could be diastereoselectively converted into (2R,4R)- or (2S,4R)-N-acetyl-2-aryl-4-thiazolidinecarboxylic acids (4 and 5, resp.).The diastereomers can be d