80458-74-8Relevant academic research and scientific papers
DIPHENYLBUTYPIPERIDINE AUTOPHAGY INDUCERS
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Page/Page column 7; 84-85, (2011/12/02)
Autophagy inducing compounds, methods of their preparation and use, and kits containg said compounds are disclosed herein.
Synthesis and SAR study of diphenylbutylpiperidines as cell autophagy inducers
Chen, Gang,Xia, Hongguang,Cai, Yu,Ma, Dawei,Yuan, Junying,Yuan, Chengye
scheme or table, p. 234 - 239 (2011/02/26)
A novel series of diphenylbutylpiperidines as autophagy inducers was described and extensive SAR studies resulted in derivatives (15d-e, 15i-j) with 10-fold greater activity than the lead compounds 1 and 2. Meanwhile, a new synthetic route to diphenylbutyl bromide (6) from bromobenzene and γ-butyrolactone was also reported here.
ESTERS OF 1--4-(4-CHLORO-3-TRIFLUOROMETHYLPHENYL)-4-PIPERIDINOL
Rajsner, Miroslav,Dlabac, Antonin,Protiva, Miroslav
, p. 1530 - 1533 (2007/10/02)
1--4-(4-chloro-3-trifluoromethylphenyl)-4-piperidinol (I) was transformed by reactions with acetyl chloride, decanoyl chloride and 3,4,5-trimethoxybenzoyl chloride to the esters II-IV.The acetate II, administered orally, was compared with the amino alcohol I in the tests of antiapomorphine actions in rats and dogs and was found inactive.The decanoate III, which was administered intramuscularly to dogs, proved properties of an ultra-long-acting depot neuroleptic.
