80465-10-7

Upstream product

• 3213-95-4 3-(4-methylphenyl)-5-phenyl-1H-1,2,4-triazole 
• 74-88-4 methyl iodide 
• 532-55-8 Benzoyl isothiocyanate 
• 106-38-7 para-bromotoluene 
• 19338-21-7 N'-benzoyl-4′-methylbenzohydrazide 
• 471910-32-4 3-(4-methylphenyl)-4-methyl-5-phenyl-4H-1,2,4-triazole 
• 52809-98-0 N-benzoyl-4-methylthiobenzamide 
• 60-34-4 methylhydrazine 

Relevant academic research and scientific papers

Regioselectivity in the thermal rearrangement of unsymmetrical 4-methyl-4H-1,2,4-triazoles to 1-methyl-1H-1,2,4-triazoles

The rearrangement of 4-methyl-3,5-diaryl-4H-1,2,4-triazoles to the corresponding 1-methyl-3,5-diaryl-1H-1,2,4-triazoles showed regioselectivity comparable to that observed for the alkylation of 3,5-diaryl-1H-1,2,4-triazoles. This lends support to a proposed mechanism for the rearrangement that involves consecutive nucleophilic displacements steps.

Heterocycles from N-Benzoylthioamides and Dinucleophilic Reagents

N-Benzoylthioamides (I) react with hydrazines and hydroxylamine to form 1H-1,2,4-triazoles and 1,2,4-oxazoles, respectively.A similar treatment of the S-methyl derivatives of 1 with amidines leads to 1,3,5-triazines.Ethyl N-benzoylthiocarbamate undergoes analogous reactions to yield the corresponding ethoxyheterocycles.